Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/46740
Title: Aniba rosaeodora (Var. amazonica Ducke) Essential Oil: Chemical Composition, Antibacterial, Antioxidant and Antitrypanosomal Activity
Authors: Teles, Amanda Mara
Silva, João Victor Silva
Fernandes, Juan Matheus Pereira
Calabrese, Kátia da Silva
Silva, Ana Lucia Abreu
Marinho, Silvio Carvalho
Mouchrek, Adenilde Nascimento
Mouchrek Filho, Victor Elias
Souza, Fernando Almeida
Affilliation: Universidade Federal do Maranhão. Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Maranhão. Pós-graduação em Ciência Animal. São Luis, MA, Brasil.
Universidade Federal do Maranhão. Laboratório de Óleos Essenciais. São Luis, MA, Brasil.
Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luis, MA, Brasil.
Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luis, MA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Maranhão. Pós-graduação em Ciência Animal. São Luis, MA, Brasil.
Abstract: Aniba rosaeodora is one of the most widely used plants in the perfumery industry, being used as medicinal plant in the Brazilian Amazon. This work aimed to evaluate the chemical composition of A. rosaeodora essential oil and its biological activities. A. rosaeodora essential oil presented linalool (93.60%) as its major compound. The A. rosaeodora essential oil and linalool showed activity against all the bacteria strains tested, standard strains and marine environment bacteria, with the lower minimum inhibitory concentration being observed for S. aureus. An efficient antioxidant activity of A. rosaeodora essential oil and linalool (EC50: 15.46 and 6.78 µg/mL, respectively) was evidenced by the inhibition of the 2,2-azinobis- (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical. The antitrypanosomal activity of A. rosaeodora essential oil and linalool was observed at high concentra tions against epimatigote forms (inhibitory concentration for 50% of parasites (IC50): 150.5 ± 1.08 and 198.6 ± 1.12 µg/mL, respectively), and even higher against intracellular amastigotes of T. cruzi (IC50: 911.6 ± 1.15 and 249.6 ± 1.18 µg/mL, respectively). Both A. rosaeodora essential oil and linalool did not exhibit a cytotoxic effect in BALB/c peritoneal macrophages, and both reduced nitrite levels in unstimulated cells revealing a potential effect in NO production. These data revealed the pharmacological potential of A. rosaeodora essential oil and linalool, encouraging further studies.
Keywords: Rosewood
Linalool
Marine bacteria
ABTS
Trypanosoma cruzi
Cytotoxicity
Nitrite
Nitric oxide
keywords: Trypanosoma cruzi
Pau Rosa
Linalol
Bactérias marinhas
Citotoxicidade
Nitrito
Òxido nítrico
ABTS
Issue Date: 2021
Publisher: MDPI
Citation: TELES, Amanda Mara et al. Aniba rosaeodora (Var. amazonica Ducke) Essential Oil: Chemical Composition, Antibacterial, Antioxidant and Antitrypanosomal Activity. Antibiotics, v. 10, n. 24, 16p, 2021.
DOI: 10.3390/antibiotics10010024
ISSN: 2079-6382
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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