Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/46743
Title: The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
Authors: Martins, Caroline Azevedo
Santos, Maria Conceição B dos
Albuquerque, Cassiano Felippe Gonçalves de
Faria Neto, Hugo Caire Castro
Faria, Mauro Velho Castro
Burth, Patricia
Younes-Ibrahim, Mauricio
Affilliation: Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil
niversidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil / Pontifícia Universidade Católica. Departamento de Medicina. Rio de Janeiro, RJ, Brasil.
Abstract: Human leptospirosis is an acute infectious zoonosis presenting specific lipid disorders. Previous in vitro studies showed both leptospira glycolipoprotein endotoxin, and high oleic acid levels were associated with Na/K-ATPase inhibition that is amplified by the reduction of circulating albumin levels. In this study, we aimed to investigate the relationship of oleic acid/albumin (OA/A) molar ratio and clinical outcomes in Leptospirosis. Through a prospective observational cohort study employing high-performance liquid chromatography (HPLC) we sequen tially determined serum concentrations of nonesterified fatty acids (NEFA) and albumin in twenty-eight patients with severe leptospirosis since their hospital admission. Twenty patients recovered, and eight died. Data was distributed in two groups according to clinical outcomes. Oleic acid/albumin molar ratios (OA/A), initial samples, were higher than those in healthy donors. The ratio OA/A, however, persisted high in dying patients, whereas patients who survived had a reduction matching to healthy donors. Biochemical alterations suggest that cure is correlated to the reestablishment of the OA/A molar ratio, while fatal outcomes related to persisting OA/A im balances. Analysis by receiver operating characteristic (ROC) showed the area under the curve of 0.864 and the cutoff value of 0.715 being associated with a high odds ratio. Lipid analysis from patients with leptospirosis had an acute high serum OA/A molar ratio, and sustained imbalance has a high odds ratio and strong correlation with mortality.
Keywords: Leptospirosis clinical outcome
Acute lipotoxicity
Lipidome
Oleic acid/albumin
Na/K-ATPase
keywords: Resultado clínico da Leptospirose
Lipotoxicidade aguda
Lipidome
Ácido oleico/albumina
Na/K-ATPase
Issue Date: 2021
Publisher: Elsevier
Citation: MARTINS, Caroline Azevedo et al. The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis. Helyon, v. 7, e06430, 7p, Mar. 2021.
DOI: 10.1016/j.heliyon.2021.e06420
ISSN: 2405-8440
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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