Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
- BA - IGM - Artigos de Periódicos [3813]
- IOC - Artigos de Periódicos [12969]
Metadata
Show full item record
INCIDENCE OF THYROID DISEASES: RESULTS FROM THE BRAZILIAN LONGITUDINAL STUDY OF ADULT HEALTH (ELSA-BRASIL)
ELSA-Brasil
Doenças da tireoide subclínica
Hipertiroidismo
Hipotireoidismo
Incidência
Subclinical thyroid diseases
Hyperthyroidism
Hypothyroidism
Incidence
ELSA-Brasil
Author
Affilliation
Abstract
Objective: To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism. Subjects
and methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study
of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705
participants with normal thyroid function at baseline, follow-up information about thyroid function and
with no report of using drugs that may interfere in the thyroid function. Thyroid function was defined by
TSH/FT4 levels or routine use of thyroid hormones/anti-thyroid medications. Annual and cumulative (over
4-year) incidence rates were presented as percentages (95% Confidence Intervals). Results: The incidence
of all overt and subclinical thyroid disease was 6.7% (1.73%/year): 0.19% for overt hyperthyroidism (0.048%/
year), 0.54% for subclinical hyperthyroidism (0.14%/year), 1.98% for overt hypothyroidism (0.51%/year),
and 3.99% for subclinical hypothyroidism (1.03%/year). The incidence of all thyroid diseases was higher in
women, when compared to men, with a low women:men ratio (1.36). For Blacks the highest incidence was
for overt hyperthyroidism, while for Whites, the highest incidence was for overt hypothyroidism. However,
the highest incidence of overt hyperthyroidism was detected in Asian descendants. The presence of
antithyroperoxidase antibodies at baseline was associated with higher incidence of overt thyroid diseases.
Conclusions: These results showed a high incidence of hypothyroidism, which is compatible with a
country with a more-than-adequate iodine intake. The low women:men ratio of the incidence of thyroid
dysfunction highlights the importance of the diagnosis of thyroid diseases among men in Brazil.
Keywords in Portuguese
Overt thyroid diseasesELSA-Brasil
Doenças da tireoide subclínica
Hipertiroidismo
Hipotireoidismo
Incidência
Keywords
Overt thyroid diseasesSubclinical thyroid diseases
Hyperthyroidism
Hypothyroidism
Incidence
ELSA-Brasil
Share