| Author | Felix, Daniele Mendes | |
| Author | Alencar, Luciana Magalhães Rebelo | |
| Author | Menezes, Frederico Duarte de | |
| Author | Midlej, Victor do Valle Pereira | |
| Author | Aguiar, Lorayne | |
| Author | Piperni, Sara Gemini | |
| Author | Zhang, Jian | |
| Author | Liu, Yin | |
| Author | Ricci Junior, Eduardo | |
| Author | Alexis, Frank | |
| Author | Alves Junior, Severino | |
| Author | Zhu, Lin | |
| Author | Oliveira, Ràlph Santos | |
| Access date | 2021-05-01T19:03:30Z | |
| Available date | 2021-05-01T19:03:30Z | |
| Document date | 2021 | |
| Citation | FELIX, Daniele Mendes et al. Graphene quantum dots decorated with imatinib for leukemia treatment. Journal of Drug Delivery Science and Technology, v. 61, 102117, 7p, Feb. 2021. | pt_BR |
| ISSN | 1773-2247 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46999 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Entrega de medicamentos | pt_BR |
| Subject in Portuguese | Ponto quântico de grafeno | pt_BR |
| Subject in Portuguese | Dispositivo biomédico | pt_BR |
| Subject in Portuguese | Material inteligente | pt_BR |
| Subject in Portuguese | Nano-partícula | pt_BR |
| Title | Graphene quantum dots decorated with imatinib for leukemia treatment | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jddst.2020.102117 | |
| Abstract | The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a
molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we
successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction.
The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles’ in vitro behaviors were evaluated
by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines,
including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the
imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and
properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of
apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer,
particularly leukemia treatments. | pt_BR |
| Affilliation | Comissão Brasileira de Energia Nuclear. Instituto de Engenharia Nuclear. Laboratório de Nanorradiofármacos e Síntese de Novos Radiofármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Departamento de Física. São Luís, MA, Brasil. | pt_BR |
| Affilliation | Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Uniganrio. Laboratório de Estudos Multidisciplinares. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Uniganrio. Laboratório de Estudos Multidisciplinares. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy. Texas A&M University, USA. | pt_BR |
| Affilliation | Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy. Texas A&M University, USA. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Escola de Farmácia. Rio de janeiro, RJ, Brasil. | pt_BR |
| Affilliation | School of Biological Sciences and Engineering. Yachay Tech University, Urcuquí, Imbabura, Ecuador. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Exatas e da Natureza (CCEN). Departamento de Química. Laboratório de Terras Raras. Recife, PE, Brasil. | pt_BR |
| Affilliation | Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy. Texas A&M University, USA. | pt_BR |
| Affilliation | Comissão Brasileira de Energia Nuclear. Instituto de Engenharia Nuclear. Laboratório de Nanorradiofármacos e Síntese de Novos Radiofármacos. Rio de Janeiro, RJ, Brasil / Universidade Estadual da Zona Oeste. Laboratório de Radiofarmácia e Nanorradiofármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Drug delivery | pt_BR |
| Subject | Graphene quantum dot | pt_BR |
| Subject | Biomedical device | pt_BR |
| Subject | Smart material | pt_BR |
| Subject | Nanoparticle | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
