Graphene quantum dots decorated with imatinib for leukemia treatment

Comissão Brasileira de Energia Nuclear. Instituto de Engenharia Nuclear. Laboratório de Nanorradiofármacos e Síntese de Novos Radiofármacos. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Maranhão. Departamento de Física. São Luís, MA, Brasil.
Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.
Uniganrio. Laboratório de Estudos Multidisciplinares. Rio de Janeiro, RJ, Brasil.
Uniganrio. Laboratório de Estudos Multidisciplinares. Rio de Janeiro, RJ, Brasil.
Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy. Texas A&M University, USA.
Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy. Texas A&M University, USA.
Universidade Federal do Rio de Janeiro. Escola de Farmácia. Rio de janeiro, RJ, Brasil.
School of Biological Sciences and Engineering. Yachay Tech University, Urcuquí, Imbabura, Ecuador.
Universidade Federal de Pernambuco. Centro de Ciências Exatas e da Natureza (CCEN). Departamento de Química. Laboratório de Terras Raras. Recife, PE, Brasil.
Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy. Texas A&M University, USA.
Comissão Brasileira de Energia Nuclear. Instituto de Engenharia Nuclear. Laboratório de Nanorradiofármacos e Síntese de Novos Radiofármacos. Rio de Janeiro, RJ, Brasil / Universidade Estadual da Zona Oeste. Laboratório de Radiofarmácia e Nanorradiofármacos. Rio de Janeiro, RJ, Brasil.

Abstract

The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles’ in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.

Keywords in Portuguese

Entrega de medicamentos
Ponto quântico de grafeno
Dispositivo biomédico
Material inteligente
Nano-partícula

Keywords

Drug delivery
Graphene quantum dot
Biomedical device
Smart material
Nanoparticle

Publisher

Elsevier

Citation

FELIX, Daniele Mendes et al. Graphene quantum dots decorated with imatinib for leukemia treatment. Journal of Drug Delivery Science and Technology, v. 61, 102117, 7p, Feb. 2021.

DOI

10.1016/j.jddst.2020.102117

ISSN

1773-2247

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/46999

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Copyright

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