| Author | Xavier, Jadriane de Almeida | |
| Author | Silva, Thaissa L. | |
| Author | Santos, Eduardo Caio Torres | |
| Author | Vasconcelos, Camila Calado de | |
| Author | Boane, Anastacio | |
| Author | Santos, Ricardo Alexandre dos | |
| Author | Xavier, Andre Felippe A. | |
| Author | Goulart, Marília O. F | |
| Access date | 2021-05-03T13:14:34Z | |
| Available date | 2021-05-03T13:14:34Z | |
| Document date | 2021 | |
| Citation | XAVIER, Jadriane de Almeida et al. Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as potential medicines. Current Opinion in Electrochemistry, online xxx 10p, 2021. | |
| URI | https://www.arca.fiocruz.br/handle/icict/47014 | |
| Language | eng | en_US |
| Publisher | Science Direct | |
| Rights | open access | |
| Subject in Portuguese | Estresse oxidativo | pt_BR |
| Subject in Portuguese | Alquilação biorredutiva | pt_BR |
| Subject in Portuguese | Nitroreductases | pt_BR |
| Subject in Portuguese | Mecanismo molecular de ação | pt_BR |
| Subject in Portuguese | Metabolismo | pt_BR |
| Subject in Portuguese | Electrochemical parameters | pt_BR |
| Title | Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as Q6 potential medicines | en_US |
| Type | Preprint | |
| Abstract | This review discusses the state of the art, challenges, and perspectives in recent applications of nitroaromatics and nitroheteroaromatics, which are redox-bio-activated drugs or leads, in Medicinal Chemistry. It deals mainly with the elec trochemical approach toward the electron transfer-based molecular mechanisms of drug action, drug design, estimation and measurement of redox potentials, correlation of physico chemical and pharmacological data, and electrochemical studies of the main representatives of nitro-containing prodrugs, along with approaches to combat their toxicity issues, aiming at a better therapeutic profile. Electrochemical investigation plays essential roles, being strategic in the design and discovery of potential medicines. | en_US |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Universidade Federal de Alagoas. Núcleo de Ciências Exatas – NCEx. Campus de Arapiraca, Al, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Centro Universitário CESMAC. Maceió, AL, Brasil. | |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | |
| Subject | Oxidative stress | en_US |
| Subject | Bioreductive alkylation | en_US |
| Subject | Nitroreductases | en_US |
| Subject | Molecular mechanism of action | en_US |
| Subject | Metabolism | en_US |
| Subject | Electrochemical parameters | en_US |
| Embargo date | 2023 | |
