Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/47014

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Open access
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2023
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UNVEILING THE RELEVANCE OF THE REDOX CHARACTER OF NITROAROMATIC AND NITROHETEROAROMATIC COMPOUNDS AS Q6 POTENTIAL MEDICINES
Xavier, Jadriane de Almeida et al. | Date Issued: 2021
Author
Xavier, Jadriane de Almeida
Silva, Thaissa L.
Santos, Eduardo Caio Torres
Vasconcelos, Camila Calado de
Boane, Anastacio
Santos, Ricardo Alexandre dos
Xavier, Andre Felippe A.
Goulart, Marília O. F
Affilliation
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Universidade Federal de Alagoas. Núcleo de Ciências Exatas – NCEx. Campus de Arapiraca, Al, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Centro Universitário CESMAC. Maceió, AL, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Abstract
This review discusses the state of the art, challenges, and perspectives in recent applications of nitroaromatics and nitroheteroaromatics, which are redox-bio-activated drugs or leads, in Medicinal Chemistry. It deals mainly with the elec trochemical approach toward the electron transfer-based mo lecular mechanisms of drug action, drug design, estimation and measurement of redox potentials, correlation of physico chemical and pharmacological data, and electrochemical studies of the main representatives of nitro-containing prodrugs, along with approaches to combat their toxicity issues, aiming at a better therapeutic profile. Electrochemical investigation plays essential roles, being strategic in the design and discovery of potential medicines.
Keywords in Portuguese
Estresse oxidativo
Alquilação biorredutiva
Nitroreductases
Mecanismo molecular de ação
Metabolismo
Electrochemical parameters
 
Keywords
Oxidative stress
Bioreductive alkylation
Nitroreductases
Molecular mechanism of action
Metabolism
Electrochemical parameters
 
Publisher
Science Direct
Citation
XAVIER, Jadriane de Almeida et al. Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as potential medicines. Current Opinion in Electrochemistry, online xxx 10p, 2021.