Author | Santana, Monique Freire | |
Author | Pinto, Rebecca Augusta de Araújo | |
Author | Marcon, Bruna Hilzendeger | |
Author | Medeiros, Lia Carolina Soares | |
Author | Morais, Thiago Barros do Nascimento de | |
Author | Dias, Lucas Castanhola | |
Author | Souza, Lorenna Pereira de | |
Author | Melo, Gisely Cardoso de | |
Author | Monteiro, Wuelton Marcelo | |
Author | Lacerda, Marcus Vinicius Guimarães | |
Author | Val, Fernando Almeida | |
Author | Lalwani, Pritesh Jaychand | |
Author | Ferreira, Luiz Carlos de Lima | |
Access date | 2021-05-05T17:57:48Z | |
Available date | 2021-05-05T17:57:48Z | |
Document date | 2021 | |
Citation | SANTANA, Monique Freire et al. Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy. Revista da Sociedade Brasileira de Medicina Tropical, v.54, p. 1–7, 2021. | pt_BR |
ISSN | 1678-9849 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47060 | |
Language | por | pt_BR |
Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | Doença Pulmonar | pt_BR |
Title | Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0037-8682-0850-2020 | |
Abstract | Electron microscopy (EM) is a rapid and effective tool that can be used to create images of a whole spectrum of virus-host interactions and, as such, has long been used in the discovery and description of viral mechanisms. Methods: Electron microscopy was used to evaluate the pulmonary pathologies of postmortem lung sections from three patients who died from infection with SARS-associated coronavirus 2 (SARS-CoV-2), a new member of the Coronaviridae family. Results: Diffuse alveolar damage (DAD) was predominant in all three patients. The early exudative stage was characterized principally by edema and extravasation of red blood cells into the alveolar space with injury to the alveolar epithelial cells; this was followed by detachment, apoptosis, and necrosis of type I and II pneumocytes. The capillaries exhibited congestion, exposure of the basement membrane from denuded endothelial cells, platelet adhesion, fibrin thrombi, and rupture of the capillary walls. The proliferative stage was characterized by pronounced proliferation of type II alveolar pneumocytes and multinucleated giant cells. The cytopathic effect of SARS-CoV-2 was observed both in degenerated type II pneumocytes and freely circulating in the alveoli, with components from virions, macrophages, lymphocytes, and cellular debris. Conclusions: Viral particles consistent with the characteristics of SARS-CoV-2 were observed mainly in degenerated pneumocytes, in the endothelium, or freely circulating in the alveoli. In the final stage of illness, the alveolar spaces were replaced by fibrosis. | pt_BR |
Affilliation | Fundação Centro de Controle de Oncologia do Estado do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brasil. / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Hospital Universitário Getúlio Vargas. Programa de Residência Médica em Patologia. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas & Maria Deane. Manaus, AM, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Pesquisas da Amazônia. Laboratório Temático de Microscopia e Nanotecnologia. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. / Universidade Federal do Amazonas. Programa de Pós-Graduação em Ciências da Saúde. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas & Maria Deane. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. / Hospital Universitário Getúlio Vargas. Programa de Residência Médica em Patologia. Manaus, AM, Brasil. / Universidade Federal do Amazonas. Programa de Pós-Graduação em Ciências da Saúde. Manaus, AM, Brasil. | pt_BR |
Subject | Coronavirus Infections | pt_BR |
Subject | Severe Acute Respiratory Syndrome | pt_BR |
Subject | Lung Diseases | pt_BR |
Subject | Electron Microscopy | pt_BR |
Subject | Alveolar Epithelial Cells | pt_BR |
Subject | Postmortem evidence | pt_BR |
Subject in Spanish | Infecciones por Coronavirus | pt_BR |
Subject in Spanish | Síndrome Respiratorio Agudo Grave | pt_BR |
Subject in Spanish | Enfermedades Pulmonares | pt_BR |
Subject in Spanish | Microscopía Electrónica | pt_BR |
Subject in Spanish | Células Epiteliales Alveolares | pt_BR |
Subject in French | Infections à coronavirus | pt_BR |
Subject in French | Syndrome respiratoire aigu sévère | pt_BR |
Subject in French | Maladies pulmonaires | pt_BR |
Subject in French | Microscopie électronique | pt_BR |
Subject in French | Pneumocytes | pt_BR |
Subject in French | Examen postmortem | pt_BR |
DeCS | Infecções por Coronavirus | pt_BR |
DeCS | Síndrome Respiratória Aguda Grave | pt_BR |
DeCS | Pneumopatias | pt_BR |
DeCS | Microscopia Eletrônica | pt_BR |
DeCS | Células Epiteliais Alveolares | pt_BR |
DeCS | Necrópsia | pt_BR |