Author | Souza, Sergio Pinto de | pt_BR |
Author | Silveira, Marcelo Augusto Duarte | pt_BR |
Author | Souza, Bruno Solano de Freitas | pt_BR |
Author | Cabral, Julia Barros | pt_BR |
Author | Melo, Erica Batista dos Santos Galvão de | pt_BR |
Author | Nonaka, Carolina Kymie Vasques | pt_BR |
Author | Coelho, Fernanda Oliveira | pt_BR |
Author | Passos, Rogerio da Hora | pt_BR |
Access date | 2021-06-10T12:22:00Z | |
Available date | 2021-06-10T12:22:00Z | |
Document date | 2021 | |
Citation | SOUZA, Sergio Pinto de et al. Evaluation of urine SARS-COV-2 RT-PCR as a predictor of acute kidney injury and disease severity in patients with critical COVID-19. Journal of International Medical Research, v. 49, n. 5, p. 1-6, 14 May 2021. | pt_BR |
ISSN | 0300-0605 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/47608 | |
Language | eng | pt_BR |
Publisher | SAGE Publications | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Urina | pt_BR |
Subject in Portuguese | Síndrome Respiratória Aguda Grave | pt_BR |
Subject in Portuguese | Reação em cadeia da polimerase | pt_BR |
Subject in Portuguese | Lesão renal aguda | pt_BR |
Subject in Portuguese | Coronavírus | pt_BR |
Subject in Portuguese | Teste de vírus | pt_BR |
Title | Evaluation of urine SARS-COV-2 RT-PCR as a predictor of acute kidney injury and disease severity in patients with critical COVID-19 | en |
Type | Article | pt_BR |
DOI | 10.1177/03000605211015555 | pt_BR |
Abstract | Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began as an outbreak in Wuhan, China and has spread rapidly across the globe. Although most infections are mild, patients with severe and critical COVID-19 infections face deterioration of respiratory function and may also have extrapulmonary manifestations, mostly affecting the kidney, digestive tract, heart, and nervous system. Here, we prospectively evaluated the presence of SARS-CoV-2 genetic material using reverse-transcription polymerase chain reaction in urine samples obtained from patients with COVID-19 receiving critical care. Among 51 included patients, we found higher serum creatinine levels, a longer hospital stay, and more frequent need for dialysis in urine-positive patients. These findings could suggest that, in predisposed patients, a direct viral cytopathic effect may contribute to a more severe disease phenotype. | en |
Affilliation | Hospital São Rafael. Nefrologia. Salvador, BA, Brasil / Hospital Santo Antônio. Medicina Interna. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Nefrologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto D'Or de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Nefrologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Nefrologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Nefrologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Nefrologia. Salvador, BA, Brasil. | pt_BR |
Subject | Urine | en |
Subject | Severe acute respiratory syndrome coronavirus 2 | en |
Subject | Polymerase chain reaction | en |
Subject | Acute kidney injury | en |
Subject | Coronavirus disease 2019 | en |
Subject | Virus testing | en |
e-ISSN | 1473-2300 | pt_BR |