Title:	Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice
Authors:	Oliveira, Maria Talita Pacheco de Coutinho, Diego de Sá Guterres, Sílvia Stanisçuaski Pohlmann, Adriana Raffin Silva, Patrícia Machado Rodrigues e Martins, Marco Aurélio Bernardi, Andressa
Affilliation:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós-Graduação em Ciências Farmacêuticas. Porto Alegre, RS, Brasil. Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós-Graduação em Ciências Farmacêuticas. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Instituto de Química. Departamento de Química Orgânica. Porto Alegre, RS, Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
Abstract:	Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are inflammatory and oxidative imbalance lung conditions with no successful pharmacological therapy and a high mortality rate. Resveratrol (RSV) is a plant-derived stilbene that presents anti-inflammatory and an tioxidant effects. However, its therapeutic application remains limited due to its poor bioavailability, which can be solved by the use of nanocarriers. Previously, we demonstrated that nanoencapsulated RSV (RSV-LNC) pre-treatment, performed 4 h before lipopolysaccharide (LPS) stimulation in mice, increased its anti-inflammatory properties. In this study, we evaluated the anti-inflammatory and antioxidant effects, and lung distribution of RSV-LNCs administered therapeutically (6 h post LPS exposure) in a lung injury mouse model. The results showed that RSV-LNCs posttreatment improved lung function and diminished pulmonary inflammation. Moreover, RSV-LNC treatment enhanced the antioxidant catalase level together with a decrease in the oxidative biomarker in mouse lungs, which was accompanied by an increase in pulmonary Nrf2 antioxidant expression. Finally, the presence of RSV in lung tissue was significantly detected when mice received RSV-LNCs but not when they received RSV in its free form. Together, our results confirm that RSV nanoencapsulation promotes an increase in RSV bioavailability, enhancing its therapeutic effects in an LPS-induced lung injury model.
Keywords:	Acute lung injury Acute respiratory distress syndrome Inflammation LPS Resveratrol Nanocarriers
keywords:	Lesão pulmonar aguda Síndrome do desconforto respiratório agudo Inflamação Receptores de Lipopolissacarídeos Resveratrol
DeCS:	Receptores de Lipopolissacarídeos
Issue Date:	2021
Publisher:	MDPI
Citation:	OLIVEIRA, Maria Talita Pacheco de et al. Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice. Pharmaceutics, v. 13, n.683, 17 p, May 2021.
DOI:	10.3390/pharmaceuthics13050683
ISSN:	1999-4923
Copyright:	open access
Appears in Collections:	IOC - Artigos de Periódicos

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