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SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 P.2 LINEAGE ASSOCIATED WITH REINFECTION CASE, BRAZIL, JUNE–OCTOBER 2020
Linhagem associada com reinfecção
Brasil
COVID-19
Rede Genômica Fiocruz
GENOMAHCOV
Severe acute respiratory syndrome
Lineage
Reinfection case
Brazil, June-October 2020
SARS-CoV-2
COVID-19
Author
Affilliation
Abstract
A 37-year-old healthcare worker from the northeastern region of Brazil experienced 2 clinical episodes of coronavirus disease. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by reverse transcription PCR in samples collected 116 days apart. Whole-genome sequencing revealed that the 2 infections were caused by the most prevalent lineage in Brazil, B.1.1.33, and the emerging lineage P.2. The first infection occurred in June 2020; Bayesian analysis suggests reinfection at some point during September 14–October 11, 2020, a few days before the second episode of coronavirus disease. Of note, P.2 corresponds to an emergent viral lineage in Brazil that contains the mutation E484K in the spike protein. The P.2 lineage was initially detected in the state of Rio de Janeiro, and since then it has been found throughout the country. Our findings suggest not only a reinfection case but also geographic dissemination of the emerging Brazil clade P.2.
Keywords in Portuguese
SARS-CoV-2Linhagem associada com reinfecção
Brasil
COVID-19
Rede Genômica Fiocruz
GENOMAHCOV
Keywords
Coronavirus 2Severe acute respiratory syndrome
Lineage
Reinfection case
Brazil, June-October 2020
SARS-CoV-2
COVID-19
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