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EPIDEMIOLOGIC HISTORY AND GENETIC DIVERSITY ORIGINS OF CHIKUNGUNYA AND DENGUE VIRUSES, PARAGUAY
Variação Genética
Vírus da Dengue
Chikungunya
história
Paraguai
Brasil
Author
Gräf, Tiago
Vazquez, Cynthia
Giovanetti, Marta
Nogueira, Fernanda de Bruycker
Fonseca, Vagner
Claro, Ingra Morales
Jesus, Jaqueline Goes de
Gómez, Andrea
Xavier, Joilson
Mendonça, Marcos Cesar Lima de
Villalba, Shirley
Torales, Juan
Gamarra, Maria Liz
Thézé, Julien
Filippis, Ana Maria Bispo de
Azevedo, Vasco
Oliveira, Tulio de
Franco, Leticia
Melo, Carlos Frederico Campelo de Albuquerque e
Irala, Sandra
Holmes, Edward Charles
Rico, Jairo Andrés Méndez
Alcantara, Luiz Carlos Junior
Vazquez, Cynthia
Giovanetti, Marta
Nogueira, Fernanda de Bruycker
Fonseca, Vagner
Claro, Ingra Morales
Jesus, Jaqueline Goes de
Gómez, Andrea
Xavier, Joilson
Mendonça, Marcos Cesar Lima de
Villalba, Shirley
Torales, Juan
Gamarra, Maria Liz
Thézé, Julien
Filippis, Ana Maria Bispo de
Azevedo, Vasco
Oliveira, Tulio de
Franco, Leticia
Melo, Carlos Frederico Campelo de Albuquerque e
Irala, Sandra
Holmes, Edward Charles
Rico, Jairo Andrés Méndez
Alcantara, Luiz Carlos Junior
Affilliation
"Múltipla ver em Notas"
Abstract
Paraguay has been severely aff ected by emergent Zika
and chikungunya viruses, and dengue virus is endemic.
To learn more about the origins of genetic diversity and
epidemiologic history of these viruses in Paraguay, we
deployed portable sequencing technologies to strengthen
genomic surveillance and determine the evolutionary
and epidemic history of arthropod-borne viruses (arboviruses).
Samples stored at the Paraguay National Central
Laboratory were sequenced and subjected to phylogenetic
analysis. Among 33 virus genomes generated, we
identifi ed 2 genotypes of chikungunya and 2 serotypes
of dengue virus that circulated in Paraguay during 2014–
2018; the main source of these virus lineages was estimated
to be Brazil. The evolutionary history inferred by
our analyses precisely matched the available travel history
of the patients. The genomic surveillance approach
used was valuable for describing the epidemiologic history
of arboviruses and can be used to determine the
origins and evolution of future arbovirus outbreaks.
Keywords in Portuguese
ArbovírusVariação Genética
Vírus da Dengue
Chikungunya
história
Paraguai
Brasil
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