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EPIDEMIOLOGIC HISTORY AND GENETIC DIVERSITY ORIGINS OF CHIKUNGUNYA AND DENGUE VIRUSES, PARAGUAY
Gräf, Tiago et al. | Date Issued: 2021
Author
Gräf, Tiago
Vazquez, Cynthia
Giovanetti, Marta
Nogueira, Fernanda de Bruycker
Fonseca, Vagner
Claro, Ingra Morales
Jesus, Jaqueline Goes de
Gómez, Andrea
Xavier, Joilson
Mendonça, Marcos Cesar Lima de
Villalba, Shirley
Torales, Juan
Gamarra, Maria Liz
Thézé, Julien
Filippis, Ana Maria Bispo de
Azevedo, Vasco
Oliveira, Tulio de
Franco, Leticia
Melo, Carlos Frederico Campelo de Albuquerque e
Irala, Sandra
Holmes, Edward Charles
Rico, Jairo Andrés Méndez
Alcantara, Luiz Carlos Junior
Affilliation
"Múltipla ver em Notas"
Abstract
Paraguay has been severely aff ected by emergent Zika and chikungunya viruses, and dengue virus is endemic. To learn more about the origins of genetic diversity and epidemiologic history of these viruses in Paraguay, we deployed portable sequencing technologies to strengthen genomic surveillance and determine the evolutionary and epidemic history of arthropod-borne viruses (arboviruses). Samples stored at the Paraguay National Central Laboratory were sequenced and subjected to phylogenetic analysis. Among 33 virus genomes generated, we identifi ed 2 genotypes of chikungunya and 2 serotypes of dengue virus that circulated in Paraguay during 2014– 2018; the main source of these virus lineages was estimated to be Brazil. The evolutionary history inferred by our analyses precisely matched the available travel history of the patients. The genomic surveillance approach used was valuable for describing the epidemiologic history of arboviruses and can be used to determine the origins and evolution of future arbovirus outbreaks.
Keywords in Portuguese
Arbovírus
Variação Genética
Vírus da Dengue
Chikungunya
história
Paraguai
Brasil
 
Keywords
Arboviruses
Genetic Variation
Dengue Virus
Chikungunya
história
Paraguay
Brazil
 
Publisher
Centers for Disease Control and Prevention
Citation
GRAF, Tiago et al. History and Genetic Diversity Origins of Chikungunya and Dengue Viruses, Paraguay. Emerging Infectious Diseases, v. 27, n. 5, p. 1393-1404, may, 2021.
DOI
10.3201/eid2705.204244
ISSN
1080-6040
Notes
Fundação Oswaldo Cruz, Salvador, Brazil (T. Gräf, J.G. de Jesus); Fundação Oswaldo Cruz, Rio de Janeiro, Brazil (C. Vazquez, M. Giovanetti, F. de Bruycker-Nogueira, V. Fonseca, J. Xavier, M.C.L. de Mendonça, A.M. Bispo de Filippis, L.C.J. Alcantara); Laboratorio Central de Salud Pública, Asunción, Paraguay (C. Vazquez, A. Gómez, S. Villalba, J. Torales, M.L. Gamarra); Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (M. Giovanetti, V. Fonseca, J. Xavier, V. Azevedo, L.C.J. Alcantara); University of KwaZulu-Natal, Durban, South Africa (V. Fonseca, T. de Oliveira); Universidade de São Paulo, São Paulo, Brazil (I.M. Claro); University of Oxford, Oxford, UK (J. Thézé); University of Washington, Seattle, Washington, USA (T. de Oliveira); Organización Panamericana de la Salud /Organización Mundial de la Salud, Panama City, Panama (L. Franco); Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Brazil (C.F. Campelo de Albuquerque); Dirección General de Vigilancia de la Salud Paraguay, Asunción (S. Irala); The University of Sydney, Sydney, New South Wales, Australia E.C. Holmes); Pan American Health Organization/World Health Organization, Washington, DC, USA (J.A.M. Rico)