| Author | Andrade, Bruno G. N. | |
| Author | Goris, Tobias | |
| Author | Afli, Haithem | |
| Author | Coutinho, Felipe H. | |
| Author | Dávila, Alberto M. R. | |
| Author | Cuadrat, Rafael R. C. | |
| Access date | 2021-07-29T14:43:53Z | |
| Available date | 2021-07-29T14:43:53Z | |
| Document date | 2021 | |
| Citation | ANDRADE, Bruno G. N. et al. Putative mobilized colistin resistance genes in the human gut microbiome. BMC Microbiology, v. 21, n. 220, 10 p, 2021. | pt_BR |
| ISSN | 1471-2180 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48406 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Colistina | pt_BR |
| Subject in Portuguese | Microbioma humano | pt_BR |
| Subject in Portuguese | Metagenômica | pt_BR |
| Subject in Portuguese | Genes de resistência a antibióticos | pt_BR |
| Title | Putative mobilized colistin resistance genes in the human gut microbiome | pt_BR |
| Type | Article | |
| DOI | 10.1186/s12866-021-02281-4 | |
| Abstract | The high incidence of bacterial genes that confer resistance to last-resort antibiotics, such as colistin,
caused by mobilized colistin resistance (mcr) genes, poses an unprecedented threat to human health.
Understanding the spread, evolution, and distribution of such genes among human populations will help in the
development of strategies to diminish their occurrence. To tackle this problem, we investigated the distribution and
prevalence of potential mcr genes in the human gut microbiome using a set of bioinformatics tools to screen the
Unified Human Gastrointestinal Genome (UHGG) collection for the presence, synteny and phylogeny of putative
mcr genes, and co-located antibiotic resistance genes. | pt_BR |
| Affilliation | Department of Computer Science, Munster Technological University, MTU/ ADAPT. Cork, Ireland. | pt_BR |
| Affilliation | Department of Molecular Toxicology, Research Group Intestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – DIfE, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. | pt_BR |
| Affilliation | Department of Computer Science, Munster Technological University, MTU/ ADAPT. Cork, Ireland. | pt_BR |
| Affilliation | Departamento de producción vegetal y microbiología. Universidad Miguel Hernández. Alicante, Spain. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e de Sistemas. Programa de Pós-Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Bioinformatics and Omics Data Science, Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center (MDC), Berlin, Germany / Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. | pt_BR |
| Subject | Colistin | pt_BR |
| Subject | Human microbiome | pt_BR |
| Subject | MCR | pt_BR |
| Subject | Metagenomics | pt_BR |
| Subject | Antibiotic resistance genes | pt_BR |
