Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/48406

Type
Article
Copyright
Open access
Collections
Share

Statistics
Metadata
Show full item record

PUTATIVE MOBILIZED COLISTIN RESISTANCE GENES IN THE HUMAN GUT MICROBIOME
Andrade, Bruno G. N. et al. | Date Issued: 2021
Author
Andrade, Bruno G. N.
Goris, Tobias
Afli, Haithem
Coutinho, Felipe H.
Dávila, Alberto M. R.
Cuadrat, Rafael R. C.
Affilliation
Department of Computer Science, Munster Technological University, MTU/ ADAPT. Cork, Ireland.
Department of Molecular Toxicology, Research Group Intestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – DIfE, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Department of Computer Science, Munster Technological University, MTU/ ADAPT. Cork, Ireland.
Departamento de producción vegetal y microbiología. Universidad Miguel Hernández. Alicante, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e de Sistemas. Programa de Pós-Graduação em Biodiversidade e Saúde. Rio de Janeiro, RJ, Brasil.
Bioinformatics and Omics Data Science, Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center (MDC), Berlin, Germany / Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Abstract
The high incidence of bacterial genes that confer resistance to last-resort antibiotics, such as colistin, caused by mobilized colistin resistance (mcr) genes, poses an unprecedented threat to human health. Understanding the spread, evolution, and distribution of such genes among human populations will help in the development of strategies to diminish their occurrence. To tackle this problem, we investigated the distribution and prevalence of potential mcr genes in the human gut microbiome using a set of bioinformatics tools to screen the Unified Human Gastrointestinal Genome (UHGG) collection for the presence, synteny and phylogeny of putative mcr genes, and co-located antibiotic resistance genes.
Keywords in Portuguese
Colistina
Microbioma humano
Metagenômica
Genes de resistência a antibióticos
 
Keywords
Colistin
Human microbiome
MCR
Metagenomics
Antibiotic resistance genes
 
Publisher
BMC
Citation
ANDRADE, Bruno G. N. et al. Putative mobilized colistin resistance genes in the human gut microbiome. BMC Microbiology, v. 21, n. 220, 10 p, 2021.
DOI
10.1186/s12866-021-02281-4
ISSN
1471-2180