| Author | Rodrigues, Pedro Mendes de Azambuja | |
| Author | Valente, Richard Hemmi | |
| Author | Brunoro, Giselle Villa Flor | |
| Author | Nakaya, HelderTakashi Imoto | |
| Author | Pereira, Mariana Araújo | |
| Author | Bozza, Patrícia T. | |
| Author | Bozza, Fernando A. | |
| Author | Trugilho, Monique Ramos de Oliveira | |
| Access date | 2021-08-09T18:01:59Z | |
| Available date | 2021-08-09T18:01:59Z | |
| Document date | 2021 | |
| Citation | RODRIGUES, Pedro Mendes de Azambuja et al. Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock. Scientific Reports, v. 11, 15149, p. 1-10, 2021. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48516 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Proteômica | pt_BR |
| Subject in Portuguese | Distúrbios | pt_BR |
| Subject in Portuguese | Resposta imunológica | pt_BR |
| Subject in Portuguese | Energia | pt_BR |
| Subject in Portuguese | Metabolismo | pt_BR |
| Subject in Portuguese | Monócitos | pt_BR |
| Subject in Portuguese | Choque térmico | pt_BR |
| Subject in Portuguese | Pacientes | pt_BR |
| Title | Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-021-94474-0 | pt_BR |
| Abstract | Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or hypoimmune
states. Monocytes are central regulators of the infammatory response, but our understanding of
their role in the genesis and resolution of sepsis is still limited. Here, we report a comprehensive
exploration of monocyte molecular responses in a cohort of patients with septic shock via proteomic
profling. The acute stage of septic shock was associated with an impaired infammatory phenotype,
indicated by the down-regulation of MHC class II molecules and proinfammatory cytokine pathways.
Simultaneously, there was an up-regulation of glycolysis enzymes and a decrease in proteins
related to the citric acid cycle and oxidative phosphorylation. On the other hand, the restoration of
immunocompetence was the hallmark of recovering patients, in which an upregulation of interferon
signaling pathways was a notable feature. Our results provide insights into the immunopathology
of sepsis and propose that, pending future studies, immunometabolism pathway components could
serve as therapeutic targets in septic patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxonologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxonologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Ciências Farmacêuticas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Ciências Farmacêuticas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxonologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Sáude. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Proteomics reveals | pt_BR |
| Subject | Disturbances | pt_BR |
| Subject | Immune response | pt_BR |
| Subject | Energy | pt_BR |
| Subject | Metabolism | pt_BR |
| Subject | Monocytes | pt_BR |
| Subject | Patients | pt_BR |
| Subject | Septic chock | pt_BR |
| xmlui.metadata.dc.subject.ods | 07 Energia limpa e acessível | |
