| Author | Franca, Mônica | |
| Author | Guimarães, Luiz H. | |
| Author | Nascimento, Maurício T. | |
| Author | Rocha, Paulo N. | |
| Author | Carvalho, Lucas Pedreira de | |
| Access date | 2021-08-19T12:41:46Z | |
| Available date | 2021-08-19T12:41:46Z | |
| Document date | 2021 | |
| Citation | FRANCA, Mõnica et al. The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials. Microbes and Infection, 2021. | |
| URI | https://www.arca.fiocruz.br/handle/icict/48665 | |
| Sponsorship | National Institutes of Health [AI136862. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | open access | |
| Subject in Portuguese | Leishmaniose cutânea | pt_BR |
| Subject in Portuguese | Terapêutica | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Title | The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis 3 is linked to disease progression but not to the therapeutic failure of pentavalent 4 antimonials | en_US |
| Type | Preprint | |
| Abstract | High levels of pro-inflammatory cytokines in cutaneous leishmaniasis patients are associated with tissue damage and ulcer development. We found higher levels of TNF and IL-1in peripheral blood mononuclear cell supernatants in response to soluble Leishmania antigen in individuals with a longer duration of disease. In addition, L. braziliensis-infected patients with a longer disease progression before treatment presented a shorter time to cure after treatment onset. No associations were found between the levels of the pro-inflammatory cytokines IL-6, TNF and IL-1- and patients’ response to pentavalent antimony treatment. Our data suggest that while the Leishmania antigen-specific pro-inflammatory cytokines investigated may lead to ulcer development, they do not influence therapeutic failure in cutaneous leishmaniasis patients. | en_US |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal do Sul da Bahia. Teixeira de Freitas, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil. | |
| Subject | Cutaneous leishmaniasis | en_US |
| Subject | Therapeutic failure | en_US |
| Subject | Cytokines | en_US |
