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THE LEISHMANIA ANTIGEN-SPECIFIC PRO-INFLAMMATORY RESPONSE IN CUTANEOUS LEISHMANIASIS 3 IS LINKED TO DISEASE PROGRESSION BUT NOT TO THE THERAPEUTIC FAILURE OF PENTAVALENT 4 ANTIMONIALS
Franca, Mônica et al. | Date Issued: 2021
Author
Franca, Mônica
Guimarães, Luiz H.
Nascimento, Maurício T.
Rocha, Paulo N.
Carvalho, Lucas Pedreira de
Affilliation
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal do Sul da Bahia. Teixeira de Freitas, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil.
Abstract
High levels of pro-inflammatory cytokines in cutaneous leishmaniasis patients are associated with tissue damage and ulcer development. We found higher levels of TNF and IL-1in peripheral blood mononuclear cell supernatants in response to soluble Leishmania antigen in individuals with a longer duration of disease. In addition, L. braziliensis-infected patients with a longer disease progression before treatment presented a shorter time to cure after treatment onset. No associations were found between the levels of the pro-inflammatory cytokines IL-6, TNF and IL-1- and patients’ response to pentavalent antimony treatment. Our data suggest that while the Leishmania antigen-specific pro-inflammatory cytokines investigated may lead to ulcer development, they do not influence therapeutic failure in cutaneous leishmaniasis patients.
Keywords in Portuguese
Leishmaniose cutânea
Terapêutica
Citocinas
 
Keywords
Cutaneous leishmaniasis
Therapeutic failure
Cytokines
 
Publisher
Elsevier
Citation
FRANCA, Mõnica et al. The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials. Microbes and Infection, 2021.