Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12967]
Metadata
Show full item record
MOLECULAR SURVEILLANCE OF THE ON-GOING SARS-COV-2 EPIDEMIC IN RIBEIRAO PRETO CITY, BRAZIL
Author
Affilliation
Abstract
The Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of an unprecedented
worldwide pandemic. Brazil demonstrates one of the highest numbers of confirmed SARS-CoV-2 cases, and Sao ˜
Paulo State is the epicenter of the pandemics in the country. Nevertheless, little is known about the SARS-CoV-2
circulation in other cities in the State than S˜
ao Paulo city. The objective of this study was to analyze phyloge netically SARS-CoV-2 strains circulating in city of Ribeir˜
ao Preto at the beginning of the pandemic and during the
actual second wave. Twenty-nine nasopharyngeal SARS-CoV-2 RNA positive samples were sequenced by nano pore technology (18 obtained at the initial period of the pandemic and 11 during the second wave) and analyzed
them phylogenetically. The performed analysis demonstrated that the majority of the strains obtained in the
initial period of the pandemic in Ribeir˜
ao Preto belonged mainly to the B1.1.33 lineage (61.1%), but B.1.1
(27.8%) and B.1.1.28 (11.1%) lineages were also identified. In contrast, the second wave strains were composed
exclusively by the Brazilian variant of concern (VOC) P.1 (91%) and P.2 (9%) lineages. The obtained phyloge netic results were suggestive of successive SARS-CoV-2 lineage substitution in this Brazilian region by the P.1
VOC. The performed study examines the SARS-CoV-2 genotypes in Ribeir˜
ao Preto city via genomic surveillance
data. The obtained findings can contribute for continuous long-term genomic surveillance of SARS-CoV-2 due to
the accelerated dynamics of viral lineage substitution, predict further waves and examine lineage behavior
during SARS-CoV-2 vaccination.
Share