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G6PD DEFICIENCY IN BLOOD DONORS OF MANAUS, AMAZON REGION, NORTHERN BRAZIL
Ferreira, Natália Santos et al. | Date Issued: 2021
Author
Ferreira, Natália Santos
Anselmo, Fernanda Cozendey
Albuquerque, Sérgio Roberto Lopes
Sanguino, Edalton Cesar Bezerra
Fraiji, Nelson Abrahim
Marinho, Gabriel Borel
Gonçalves, Marilda Souza
Moura Neto, José Pereira de
Affilliation
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil.
Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme present in the cytoplasm of all cells in the human body, and its purpose is to assist in the production of substances that protect them from being destroyed. Red blood cells depend exclusively on this enzyme as the only source of NADPH production and the main protection against oxidative stress. When G6PD function is deficient, there is insufficient NADPH production for detoxification when the production of reactive oxygen species (ROS) increases, which contributes to oxidative damage and early hemolysis.
Keywords in Portuguese
Doadores de sangue
Anemia
Glucose-6-Fosfato
Mutação
Brasil
 
Keywords
G6PD
Blood donors
Polymorphism
 
Publisher
Wiley
Citation
FERREIRA, Natália Santos et al. G6PD deficiency in blood donors of Manaus, Amazon Region, northern Brazil. International Journal of Laboratory Hematology, p. 1-4, 13 May 2021.
DOI
10.1111/ijlh.13574
ISSN
1751-5521