Access date | 2021-08-31T14:23:08Z | |
Available date | 2021-08-31T14:23:08Z | |
Document date | 2019 | |
Citation | SOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. CA Pat. 3105326, 25 jul. 2019. 65p. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48855 | |
Language | eng | pt_BR |
Publisher | Canadian Intelectual Property Office | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Asparaginase | pt_BR |
Subject in Portuguese | Câncer | pt_BR |
Title | Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide | pt_BR |
Alternative title | Polypeptide a activite asparaginase, cassette d'expression, vecteur d'expression, cellule hote, composition pharmaceutique, procedes pour produire un polypeptide a activite aspara ginase et pour prevenir ou traiter le cancer, et utilisation d'un polypeptide | pt_BR |
Type | Patent | pt_BR |
Abstract | The present invention relates to polypeptides with asparaginase activity, which have an increased self-processing rate in comparison to wild-type human L-asparaginase (ASRGL1), said polypeptides having a mutation in the glycine-rich loop of ASRGL1, denominated the HGG (Histidine 8-Glycine 9-Glycine 10) loop. Polynucleotides encoding the polypeptides of the invention, expression cassettes comprising said polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the polypeptide of the invention in manufacturing a medication for preventing or treating cancer, and methods for producing the polypeptide of the invention and for preventing or treating cancer are also described herein. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Subject | Asparaginase | pt_BR |
Subject | Cancer | pt_BR |
Inventor | Souza, Tatiana de Arruda Campos Brasil de | pt_BR |
Inventor | Zanchin, Nilson Ivo Tonin | pt_BR |
Inventor | Morais, Stephanie Bath de | pt_BR |
Patent holder | Fundação Oswaldo Cruz | pt_BR |
IPC number | A61K 38/50 | |
IPC number | A61P 35/02 | |
IPC number | C12N 15/66 | |
IPC number | A61P 35/00 | |
IPC number | C12N 15/55 | |
Filling number | CA3105326A1 | pt_BR |
Priority number | BR102018001033-6A2 | pt_BR |
Filing date | 2020-07-16 | |
Publication number | CA3105326A1 | pt_BR |
Country | Brasil | pt_BR |
Country | Organização Mundial para Propriedade Intelectual OMPI | pt_BR |
Country | Estados Unidos da América | pt_BR |
Country | Escritório de Patentes Europeu | pt_BR |
Country | Canadá | pt_BR |
Country | Índia | pt_BR |
Country | China | pt_BR |