Author | Sáez-Alquezar, Amadeo | |
Author | Junqueira, Angela Cristina Verissimo | |
Author | Durans, Andressa da Matta | |
Author | Guimarães, André Valpassos | |
Author | Corrêa, José Abol | |
Author | Pereira, José Borges | |
Author | Zauza, Patrícia Lago | |
Author | Cabello, Pedro Hernan | |
Author | Albajar-Viñas, Pedro | |
Author | Provance Jr., David William | |
Author | Coura, José Rodrigues | |
Access date | 2021-09-02T14:44:51Z | |
Available date | 2021-09-02T14:44:51Z | |
Document date | 2021 | |
Citation | SÁEZ-ALQUEZAR, Amadeo et al. Geographical origin of chronic Chagas disease patients in Brazil impacts the performance of commercial tests for anti-T. cruzi IgG. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210032, 7 p, 2021. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48915 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Doença de Chagas em humanos | pt_BR |
Subject in Portuguese | Testes de diagnóstico sorológico | pt_BR |
Subject in Portuguese | Imunoensaios | pt_BR |
Subject in Portuguese | Padrões de referência biológica internacional | pt_BR |
Title | Geographical origin of chronic Chagas disease patients in Brazil impacts the performance of commercial tests for anti-T. cruzi IgG | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760210032 | |
Abstract | BACKGROUND Chagas disease, caused by Trypanosoma cruzi, affects nearly six million people worldwide. Various serological
tests have been developed for its diagnosis.
OBJECTIVE Examine the performance of a set of commercial immunological assays in relation to the geographical origin of the
patient sample comparing four states of Brazil: Amazonas (AM), Mato Grosso do Sul (MS), Minas Gerais (MG) and Piauí (PI).
METHODS Seven immunoassays were employed to detect anti-T. cruzi IgG antibodies in 379 patient samples that had been
previously diagnosed using the two-step protocol required by the Brazilian Ministry of Health.
FINDINGS A significant variation in the percent reactive was calculated for the samples from AM and MS, while the PI and MG
showed a significant variation in the percent non-reactive. The average reactivity index was significantly higher for samples from
the states of PI and MG states than AM and MS.
MAIN CONCLUSIONS All tests presented a satisfactory performance overall. Yet, variations were observed that were associated
to the region of origin of the samples. Our analyses suggest that future evaluations of immunoassays should include a sampling
of sera from regions where the test will be applied in addition to the available International Biological Reference Standards. | pt_BR |
Affilliation | Sociedade Brasileira de Análises Clínicas. Programa Nacional de Controle de Qualidade. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.. Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Sociedade Brasileira de Análises Clínicas. Programa Nacional de Controle de Qualidade. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Sociedade Brasileira de Análises Clínicas. Programa Nacional de Controle de Qualidade. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Laboratório de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | World Health Organization. Department of Control of Neglected Tropical Diseases. Geneva, Switzerland. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.. Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Human Chagas disease | pt_BR |
Subject | Serological diagnostic tests | pt_BR |
Subject | Immunoassays | pt_BR |
Subject | International Biological Reference Standards | pt_BR |
e-ISSN | 1678-8060 | |