| Author | Lopes, Amanda de Oliveira | |
| Author | Spitz, Natália | |
| Author | Reis, Christian Robson de Souza | |
| Author | Paula, Vanessa Salete de | |
| Access date | 2021-09-20T21:06:43Z | |
| Available date | 2021-09-20T21:06:43Z | |
| Document date | 2021 | |
| Citation | LOPES, Amanda de Oliveira. Update of the global distribution of human gammaherpesvirus 8 genotypes. Scientific Reports, v. 11, n.7640, 9 p, 2021. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/49120 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Distribuição global | pt_BR |
| Subject in Portuguese | Atualização | pt_BR |
| Subject in Portuguese | Gammaherpesvirus humano 8 | pt_BR |
| Subject in Portuguese | Genótipos | pt_BR |
| Title | Update of the global distribution of human gammaherpesvirus 8 genotypes | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-021-87038-9 | |
| Abstract | Human gammaherpesvirus 8 (HHV-8) consists of six major clades (A–F) based on the genetic
sequence of the open reading frame (ORF)-K1. There are a few conficting reports regarding the global
distribution of the diferent HHV-8 genotypes. This study aimed to determine the global distribution
of the diferent HHV-8 genotypes based on phylogenetic analysis of the ORF-K1 coding region using
sequences published in the GenBank during 1997–2020 and construct a phylogenetic tree using the
maximum likelihood algorithm with the GTR+ I +G nucleotide substitution model. A total of 550
sequences from 38 countries/origins were analysed in this study. Genotypes A and C had similar global
distributions and were prevalent in Africa and Europe. Genotype B was prevalent in Africa. Of the rare
genotypes, genotype D was reported in East Asia and Oceania and genotype E in South America, while
genotype F was prevalent in Africa. The highest genotypic diversity was reported in the American
continent, with Brazil housing fve HHV-8 genotypes (A, B, C, E, and F). In this study, we present
update of the global distribution of HHV-8 genotypes, providing a basis for future epidemiological and
evolutionary studies of HHV-8. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Update | pt_BR |
| Subject | Global distribution | pt_BR |
| Subject | Human gammaherpesvirus 8 | pt_BR |
| Subject | Genotypes | pt_BR |
