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UPDATE OF THE GLOBAL DISTRIBUTION OF HUMAN GAMMAHERPESVIRUS 8 GENOTYPES
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Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract
Human gammaherpesvirus 8 (HHV-8) consists of six major clades (A–F) based on the genetic
sequence of the open reading frame (ORF)-K1. There are a few conficting reports regarding the global
distribution of the diferent HHV-8 genotypes. This study aimed to determine the global distribution
of the diferent HHV-8 genotypes based on phylogenetic analysis of the ORF-K1 coding region using
sequences published in the GenBank during 1997–2020 and construct a phylogenetic tree using the
maximum likelihood algorithm with the GTR+ I +G nucleotide substitution model. A total of 550
sequences from 38 countries/origins were analysed in this study. Genotypes A and C had similar global
distributions and were prevalent in Africa and Europe. Genotype B was prevalent in Africa. Of the rare
genotypes, genotype D was reported in East Asia and Oceania and genotype E in South America, while
genotype F was prevalent in Africa. The highest genotypic diversity was reported in the American
continent, with Brazil housing fve HHV-8 genotypes (A, B, C, E, and F). In this study, we present
update of the global distribution of HHV-8 genotypes, providing a basis for future epidemiological and
evolutionary studies of HHV-8.
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