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EPIDEMIOLOGY OF ENTERIC VIRUS INFECTIONS IN CHILDREN LIVING IN THE AMAZON REGION
Norovirus
Adenovírus humano
Sapovirus
Antígenos histo-sanguíneos
Amazonas
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Affilliation
Abstract
Objectives: To verify the frequency of viruses causing acute gastroenteritis (AGE) in association with the
histo-blood group antigen (HBGA) and RotarixTM vaccination coverage in children from the Amazon
region.
Design: Fecal and saliva samples were collected from children with AGE (n = 485) and acute respiratory
infection (ARI) (n = 249) clinical symptoms. Rotavirus A (RVA), norovirus, human adenovirus (HAdV), and
sapovirus (SaV) were verified in feces by molecular detection. Saliva samples were used for HBGA
phenotyping/FUT3 genotyping. Blood group types, clinical aspects and RotarixTM RVA vaccination data
were recorded.
Results: Norovirus remained the most prevalently detected cause of AGE (38%, 184/485 and ARI 21.3%, 53/
249). High HAdV frequencies were observed in AGE children (28.6%,139/485) and ARI children (37.3%, 93/
249). RVA was the third most prevalent virus causing AGE (22.7%, 110/485 and ARI 19.3%, 48/249) and a
low RV1 coverage (61%, 448/734) was verified. The SaV frequencies were lower (7.2%, 35/485 for AGE and
6.8%,17/249 for ARI). Secretor children were HBGA susceptible to HAdV infection (OR 1.5, 95% CI 1.0–2.3; P
= 0.04) but not to RVA, norovirus or SaV infection.
Conclusions: Norovirus could be considered the main etiological agent of AGE. No association was verified
for HBGA susceptibility to RVA, norovirus and SaV. Secretor children showed a slight susceptibility to
HAdV infection and the Le (a-b-) heterogeneous SNPs on the FUT3 gene.
Keywords in Portuguese
Rotavirus ANorovirus
Adenovírus humano
Sapovirus
Antígenos histo-sanguíneos
Amazonas
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