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THE DISTRIBUTION OF CAMPYLOBACTER JEJUNI VIRULENCE GENES IN GENOMES WORLDWIDE DERIVED FROM THE NCBI PATHOGEN DETECTION DATABASE
Campylobacter jejuni
Genomas
Derivados do patógeno NCBI
Banco de dados de detecção
C. jejuni
WGS
flaA
flaB
Author
Affilliation
Abstract
Campylobacter jejuni (C. jejuni) is responsible for 80% of human campylobacteriosis and is the leading cause of gastroenteritis globally. The relevant public health risks of C. jejuni are caused by particular virulence genes encompassing its virulome. We analyzed 40,371 publicly available genomes of C. jejuni deposited in the NCBI Pathogen Detection Database, combining their epidemiologic metadata with an in silico bioinformatics analysis to increase our current comprehension of their virulome from a global perspective. The collection presented a virulome composed of 126 identified virulence factors that were grouped in three clusters representing the accessory, the softcore, and the essential core genes according to their prevalence within the genomes. The multilocus sequence type distribution in the genomes was also investigated. An unexpected low prevalence of the fulllength flagellin flaA and flaB locus of C. jejuni genomes was revealed, and an essential core virulence gene repertoire prevalent in more than 99.99% of genomes was identified. Altogether, this is a pioneer study regarding Campylobacter jejuni that has compiled a significant amount of data about the Multilocus Sequence Type and virulence factors concerning their global prevalence and distribution over this database.
Keywords in Portuguese
Distribuição dos genes de virulênciaCampylobacter jejuni
Genomas
Derivados do patógeno NCBI
Banco de dados de detecção
C. jejuni
WGS
flaA
flaB
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