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VLA-4 AS A CENTRAL TARGET FOR MODULATING NEUROINFLAMMATORY DISORDERS
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Abstract
The complex steps leading to the central nervous system
(CNS) inflammation and the progress to neuroinflammatory
and neurodegenerative disorders have opened up new research
and intervention avenues. This review focuses on the
therapeutic targeting of the VLA-4 integrin to discuss the
clear-cut effect on immune cell trafficking into brain tissues.
Besides, we explore the possibility that blocking VLA-4 may
have a relevant impact on nonmigratory activities of immune
cells, such as antigen presentation and T-cell differentiation,
during the neuroinflammatory process. Lastly, the
recent refinement of computational techniques is highlighted
as a way to increase specificity and to reduce the
detrimental side effects of VLA-4 immunotherapies aiming
at developing better clinical interventions.
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