Author | Almeida, Ray Silva de | |
Author | Ribeiro Filho, Jaime | |
Author | Freitas, Priscilla Ramos | |
Author | Araújo, Ana Carolina Justino de | |
Author | Santos, Eduardo Lourenço dos | |
Author | Tintino, Saulo Relison | |
Author | Moura, Talysson Felismino | |
Author | Ferreira, Vitória Assunção | |
Author | Ferreira, Beatriz Assunção | |
Author | Fonseca, Victor Juno Alencar | |
Author | Leite, Pedro Ivo Palacio | |
Author | Silva, Ana Cristina Albuquerque da | |
Author | Silva, Luiz Everson da | |
Author | Amaral, Wanderlei do | |
Author | Deschamps, Cícero | |
Author | Siyadatpanah, Abolghasem | |
Author | Wilairatana, Polrat | |
Author | Coutinho, Henrique Douglas Melo | |
Author | Tintino, Saulo Relison | |
Author | Moura, Talysson Felismino | |
Author | Ferreira, Vitória Assunção | |
Author | Ferreira, Beatriz Assunção | |
Author | Fonseca, Victor Juno Alencar | |
Author | Leite, Pedro Ivo Palacio | |
Author | Silva, Ana Cristina Albuquerque da | |
Author | Silva, Luiz Everson da | |
Author | Amaral, Wanderlei do | |
Author | Deschamps, Cícero | |
Author | Siyadatpanah, Abolghasem | |
Author | Wilairatanah, Polrat | |
Author | Coutinho, Henrique Douglas Melo | |
Access date | 2021-11-24T19:04:57Z | |
Available date | 2021-11-24T19:04:57Z | |
Document date | 2021 | |
Citation | ALMEIDA, Ray Silva de et al. Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association. Journal of Infection and Public Health, 2021. | pt_BR |
ISSN | 1876-0341 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50055 | |
Description | aLaboratório de Microbiologia e Biologia Molecular — LMBM, Universidade Regional do Cariri, Crato, CE, BrazilbGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), BrazilcCentro Universitário Christus — Unichristus, Fortaleza, CE, BrazildFaculdade Maurício de Nassau — UNINASSAU, Petrolina, PE, BrazilePost Graduate Programme in Sustainable Territorial Development, Federal University of Paraná — UFPR, Matinhos, BrazilfPost Graduate Programme in Agronomy, Federal University of Paraná — UFPR, Curitiba, BrazilgFerdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, IranhDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailanda | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Macrolídeos | pt_BR |
Subject in Portuguese | Aminoglicosídeos | pt_BR |
Subject in Portuguese | Rresistência aos antibióticos | pt_BR |
Subject in Portuguese | Safrol | pt_BR |
Subject in Portuguese | Ocotea | pt_BR |
Title | Enhancement of the antibiotic activity mediated by the essential oil ofOcotea odorifera (VELL) ROWHER and safrole association | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jiph.2021.09.028 | |
Abstract | In a recent study, our research group demonstrated that the essential oil of Ocotea odorifera (EOOO)and its major compound safrole potentiated the action fluoroquinolones, modulating bacterial resistancepossibly due to direct inhibition of efflux pumps. Thus, in the present study, we investigated whether thesetreatments could enhance the activity of gentamicin and erythromycin against multidrug-resistant (MDR)bacteria. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed bygas chromatography coupled to mass spectrometry (GC–MS). The antibiotic-enhancing effect of the EOOOand safrole against MDR strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa wasanalyzed by the broth microdilution method. The chemical analysis confirmed the presence of safrole as amajor component among the 16 compounds identified in the EOOO. Both the essential oil and the isolatedcompound showed clinically relevant antibacterial activities against S. aureus. Regarding the modulationof antibiotic resistance, the EOOO was found to enhance the activity of erythromycin against the strains ofP. aeruginosa and S. aureus, as well as improving the action of gentamicin against S. aureus. On the otherhand, safrole potentiated the activity of gentamicin against the S. aureus strain alone. It is concluded,therefore, that the EOOO and safrole can enhance the activity of macrolides and aminoglycosides, andas such are useful in the development of therapeutic tools to combat bacterial resistance against theseclasses of antibiotics. | pt_BR |
Affilliation | "Múltipla ver em Notas" | pt_BR |
Subject | Macrolides | pt_BR |
Subject | Aminoglycosides | pt_BR |
Subject | Antibiotic resistance modulation | pt_BR |
Subject | Safrole | pt_BR |
Subject | Ocotea odoriferaa | pt_BR |