| Author | Massana, Arnau Casanovas | |
| Author | Oliveira, Daiana de | |
| Author | Schneider, Andrew G. | |
| Author | Begon, Mike | |
| Author | Childs, James E. | |
| Author | Costa, Federico | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Ko, Albert Icksang | |
| Author | Wunder Junior, Elsio Augusto | |
| Access date | 2021-11-25T18:04:02Z | |
| Available date | 2021-11-25T18:04:02Z | |
| Document date | 2021 | |
| Citation | MASSANA, Arnau Casanovas et al. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal of Infectious Diseases, 2021. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50066 | |
| Description | National Institutes of Health (grant numbers R01 AI052473,
U01 AI088752, R25 TW009338, R01 TW009504, and
R01 AI121207); and the Wellcome Trust (grant number
102330/Z/13/Z). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Reservatório ambiental | pt_BR |
| Subject in Portuguese | Leptospira interrogans | pt_BR |
| Subject in Portuguese | Leptospirose | pt_BR |
| Subject in Portuguese | Leptospira | pt_BR |
| Subject in Portuguese | Rattus norvegicus | pt_BR |
| Subject in Portuguese | Genotipagem | pt_BR |
| Subject in Portuguese | Solo | pt_BR |
| Subject in Portuguese | Agua | pt_BR |
| Title | Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/infdis/jiab323 | |
| Abstract | In this study, we genotyped samples from environmental reservoirs
(surface water and soil), colonized rat specimens, and cases
of human severe leptospirosis from an endemic urban slum in
Brazil, to determine the molecular epidemiology of pathogenic
Leptospira and identify pathways of leptospirosis infection. We
identified a well-established population of Leptospira interrogans
serovar Copenhageni common to human leptospirosis cases, and
animal and environmental reservoirs. This finding provides genetic
evidence for a potential environmental spillover pathway
for rat-borne leptospirosis through the environment in this urban
community and highlights the importance of environmental and
social interventions to reduce spillover infections. | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA. | pt_BR |
| Affilliation | Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA. | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / 4Universidade Federal da Bahia, Salvador, Bahia, Brazil. | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Affilliation | Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
| Subject | Environmental reservoir | pt_BR |
| Subject | Leptospira interrogans | pt_BR |
| Subject | Leptospirosis | pt_BR |
| Subject | Pathogenic Leptospira | pt_BR |
| Subject | Rattus norvegicus | pt_BR |
| Subject | Genotyping | pt_BR |
| Subject | Soil | pt_BR |
| Subject | Water. | pt_BR |
| xmlui.metadata.dc.subject.ods | 15 Vida terrestre | |
