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GENETIC EVIDENCE FOR A POTENTIAL ENVIRONMENTAL PATHWAY TO SPILLOVER INFECTION OF RAT-BORNE LEPTOSPIROSIS
Massana, Arnau Casanovas et al. | Date Issued: 2021
Author
Massana, Arnau Casanovas
Oliveira, Daiana de
Schneider, Andrew G.
Begon, Mike
Childs, James E.
Costa, Federico
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Wunder Junior, Elsio Augusto
Affilliation
Yale School of Public Health. New Haven, Connecticut, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Yale School of Public Health. New Haven, Connecticut, USA.
Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom,
Yale School of Public Health. New Haven, Connecticut, USA.
Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / 4Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Abstract
In this study, we genotyped samples from environmental reservoirs (surface water and soil), colonized rat specimens, and cases of human severe leptospirosis from an endemic urban slum in Brazil, to determine the molecular epidemiology of pathogenic Leptospira and identify pathways of leptospirosis infection. We identified a well-established population of Leptospira interrogans serovar Copenhageni common to human leptospirosis cases, and animal and environmental reservoirs. This finding provides genetic evidence for a potential environmental spillover pathway for rat-borne leptospirosis through the environment in this urban community and highlights the importance of environmental and social interventions to reduce spillover infections.
Keywords in Portuguese
Reservatório ambiental
Leptospira interrogans
Leptospirose
Leptospira
Rattus norvegicus
Genotipagem
Solo
Agua
 
Keywords
Environmental reservoir
Leptospira interrogans
Leptospirosis
Pathogenic Leptospira
Rattus norvegicus
Genotyping
Soil
Water.
 
Publisher
Oxford University Press
Citation
MASSANA, Arnau Casanovas et al. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal of Infectious Diseases, 2021.
DOI
10.1093/infdis/jiab323
ISSN
0022-1899
Notes
National Institutes of Health (grant numbers R01 AI052473, U01 AI088752, R25 TW009338, R01 TW009504, and R01 AI121207); and the Wellcome Trust (grant number 102330/Z/13/Z).