| Author | Leyton, Benjamin | |
| Author | Ramos, Juliana Nunes | |
| Author | Baio, Paulo Victor Pereira | |
| Author | Veras, João Flávio Carneiro | |
| Author | Souza, Cassius | |
| Author | Burkovski, Andreas | |
| Author | Guaraldi, Ana Luíza Mattos | |
| Author | Vieira, Verônica Viana | |
| Author | Marin, Michel Abanto | |
| Access date | 2021-12-12T18:06:01Z | |
| Available date | 2021-12-12T18:06:01Z | |
| Document date | 2021 | |
| Citation | LEYTON, Benjamin et L. Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum. International Journal of Molecular Sciences, v. 22, 7499, p. 1 - 17, July 2021. | pt_BR |
| ISSN | 1422-0067 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50316 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Corynebacterium striatum | pt_BR |
| Subject in Portuguese | Mecanismos de resistência a múltiplas drogas | pt_BR |
| Subject in Portuguese | Sequências de inserção | pt_BR |
| Subject in Portuguese | Transposons | pt_BR |
| Subject in Portuguese | Fenótipo MLS | pt_BR |
| Subject in Portuguese | Resistome | pt_BR |
| Subject in Portuguese | Patógeno emergente | pt_BR |
| Subject in Portuguese | plasmídeo pTP10 | pt_BR |
| Subject in Portuguese | Genes de resistência a antibióticos | pt_BR |
| Title | Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum | pt_BR |
| Type | Article | |
| DOI | 10.3390/ijms22147499 | |
| Abstract | Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also
an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial
outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing
worldwide. However, there are no studies about the genomic determinants related to antimicrobial
resistance in C. striatum. This review updates global information related to antimicrobial resistance
found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination.
The resistome of C. striatum comprises chromosomal and acquired elements. Resistance to fluoroquinolones
and daptomycin are due to mutations in chromosomal genes. Conversely, resistance
to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile
genomic elements such as plasmids and transposons. The presence and diversity of insertion
sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in
genomic rearrangements and their potential to transfer these elements to other pathogens. The
present study underlines that the resistome of C. striatum is dynamic; it is in evident expansion and
could be acting as a reservoir for ARGs. | pt_BR |
| Affilliation | Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera. Temuco, Chile / Carrera de Bioquímica, Departamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera. Temuco, Chile. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Difteria e Corinebactéria de Relevância Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Difteria e Corinebactéria de Relevância Clínica. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Department of Biology, Professur für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstrasse 5, 91058 Erlangen. Germany. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Difteria e Corinebactéria de Relevância Clínica. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera. Temuco, Chile. | pt_BR |
| Subject | Corynebacterium striatum | pt_BR |
| Subject | Multidrug resistance mechanisms | pt_BR |
| Subject | Insertion sequences | pt_BR |
| Subject | Transposons | pt_BR |
| Subject | MLS phenotype | pt_BR |
| Subject | Resistome | pt_BR |
| Subject | Emerging pathogen | pt_BR |
| Subject | pTP10 plasmid | pt_BR |
| Subject | Antibiotic resistance genes | pt_BR |
