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TREAT ME WELL OR WILL RESIST: UPTAKE OF MOBILE GENETIC ELEMENTS DETERMINE THE RESISTOME OF CORYNEBACTERIUM STRIATUM
Leyton, Benjamin et al. | Date Issued: 2021
Author
Leyton, Benjamin
Ramos, Juliana Nunes
Baio, Paulo Victor Pereira
Veras, João Flávio Carneiro
Souza, Cassius
Burkovski, Andreas
Guaraldi, Ana Luíza Mattos
Vieira, Verônica Viana
Marin, Michel Abanto
Affilliation
Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera. Temuco, Chile / Carrera de Bioquímica, Departamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera. Temuco, Chile.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Difteria e Corinebactéria de Relevância Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Difteria e Corinebactéria de Relevância Clínica. Rio de Janeiro, RJ, Brasil
Department of Biology, Professur für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstrasse 5, 91058 Erlangen. Germany.
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Difteria e Corinebactéria de Relevância Clínica. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera. Temuco, Chile.
Abstract
Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in C. striatum. This review updates global information related to antimicrobial resistance found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination. The resistome of C. striatum comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of C. striatum is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.
Keywords in Portuguese
Corynebacterium striatum
Mecanismos de resistência a múltiplas drogas
Sequências de inserção
Transposons
Fenótipo MLS
Resistome
Patógeno emergente
plasmídeo pTP10
Genes de resistência a antibióticos
 
Keywords
Corynebacterium striatum
Multidrug resistance mechanisms
Insertion sequences
Transposons
MLS phenotype
Resistome
Emerging pathogen
pTP10 plasmid
Antibiotic resistance genes
 
Publisher
MDPI
Citation
LEYTON, Benjamin et L. Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum. International Journal of Molecular Sciences, v. 22, 7499, p. 1 - 17, July 2021.
DOI
10.3390/ijms22147499
ISSN
1422-0067