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INFLAMMATORY CYTOKINE PATTERNS ASSOCIATED WITH NEUROLOGICAL DISEASES IN CORONAVIRUS DISEASE 2019
Inflammatory neurological diseases
Central nervous system
Cerebrospinal fluid
SARS-CoV-2
Author
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Abstract
Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor β1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines.
Keywords
COVID-19Inflammatory neurological diseases
Central nervous system
Cerebrospinal fluid
SARS-CoV-2
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