| Author | Campos, Fernanda Magalhães Freire | |
| Author | Santos, Marina Lima Silva | |
| Author | Kano, Flora Satiko | |
| Author | Fontes, Cor Jesus Fernandes | |
| Author | Lacerda, Marcus Vinicius Guimarães de | |
| Author | Brito, Cristiana Ferreira Alves | |
| Author | Carvalho, Luzia Helena | |
| Access date | 2021-12-29T13:06:28Z | |
| Available date | 2021-12-29T13:06:28Z | |
| Document date | 2013 | |
| Citation | CAMPOS, Fernanda Magalhães Freire et al. Genetic Variability in Platelet Integrin α2β1 Density: Possible Contributor to Plasmodium vivax–induced Severe Thrombocytopenia. Am J Trop Med Hyg., v. 88, n. 2, p. 325–328, 2013. doi: 10.4269/ajtmh.2012.12-0297 | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50554 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Plasmodium vivax | pt_BR |
| Title | Genetic variability in platelet integrin ?2?1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.4269/ajtmh.2012.12-0297 | |
| Abstract | Understanding the pathogenesis of Plasmodium vivax malaria is challenging. We hypothesized that susceptibility to P. vivax-induced thrombocytopenia could be associated with polymorphisms on relevant platelet membrane integrins: integrin ?2 (C807T), and integrin ?3 (T1565C). Although ?3 polymorphism was not related with P. vivax malaria, ?2 807T carriers, which show high levels of integrin ?2?1, had a higher probability for severe thrombocytopenia than wild-type carriers. This evidence of the association of integrin polymorphism and P. vivax morbidity was further demonstrated by a moderate but significant correlation between clinical disease and surface levels of the integrin ?2?1. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso. Cuiabá, MT, Brazil | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Malária | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
