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NON-PERMISSIVE SARS-COV-2 INFECTION IN HUMAN NEUROSPHERES
https://www.arca.fiocruz.br/handle/icict/53586
Produção científica do Laboratório de Imunofarmacologia.
Produção científica do Laboratório de Pesquisa sobre o Timo.
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Abstract
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.
Publisher
Elsevier
Citation
PEDROSA, Carolina da Silva Gouveia et al. Non-permissive SARS-CoV-2 infection in human neurospheres. Stem Cell Resarch, v. 54, p. 1-13, July 2021.Previous version
DOI
10.1016/j.scr.2021.102436ISSN
1873-5061Notes
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Produção científica do Laboratório de Imunofarmacologia.
Produção científica do Laboratório de Pesquisa sobre o Timo.
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