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INTRODUCTION OF SARS‐COV‐2 C.37 (WHO VOI LAMBDA) IN THE SAO PAULO STATE, SOUTHEAST BRAZIL
Variante lambda
Variantes de SARS-CoV-2
Variantes de interesse
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Abstract
The Lambda variants of interest (VOI) (C37/GR/452Q.V1/21G) was initially reported
in Lima, Peru but has gained rapid dissemination through other Latin American countries. Nevertheless, the dissemination and molecular epidemiology of
the Lambda VOI in Brazil is unknown apart from a single case report. In this respect,
we characterized the circulation of the SARS‐CoV‐2 Lambda VOI (C37/GR/452Q.
V1/21G) in Sao Paulo State, Brazil. From March to June 2021, we identified seven
Lambda isolates in a set of approximately 8000 newly sequenced genomes of the
Network for Pandemic Alert of Emerging SARS‐CoV‐2 variants from Sao Paulo
State. Interestingly, in three of the positive patients, the Lambda VOI infection was
probably related to a contact transmission. These individuals were fully vaccinated
to COVID‐19 and presented mild symptoms. The remaining positive for Lambda VOI
individuals showed different levels of COVID‐19 symptoms and one of them needed
hospitalization (score 5, WHO). In our study, we present a low level of Lambda VOI
circulation in the Sao Paulo State. This reinforces the essential role of molecular
surveillance for the effective SARS‐CoV‐2 pandemic response, especially in regard
to circulating variants.
Keywords in Portuguese
Epidemiologia molecularVariante lambda
Variantes de SARS-CoV-2
Variantes de interesse
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