| Author | Daliry, Anissa | |
| Author | Pereira, Evelyn Nunes Goulart da Silva | |
| Access date | 2022-01-24T18:13:20Z | |
| Available date | 2022-01-24T18:13:20Z | |
| Document date | 2021 | |
| Citation | DALIRY, Anissa; PEREIRA; Evelyn Nunes Goulart da Silva. Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders. Nutrients, v. 13, 3533, p. 1 - 21, Oct. 2021. | pt_BR |
| ISSN | 2072-6643 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50863 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Microbiota intestinal | pt_BR |
| Subject in Portuguese | Distúrbios do neurodesenvolvimento | pt_BR |
| Subject in Portuguese | Obesidade | pt_BR |
| Subject in Portuguese | Eixo intestino-cérebro | pt_BR |
| Subject in Portuguese | Dieta materna | pt_BR |
| Title | Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders | pt_BR |
| Type | Article | |
| DOI | 10.3390/nu13103533 | |
| Abstract | The rise in the prevalence of obesity and other related metabolic diseases has been paralleled
by an increase in the frequency of neurodevelopmental problems, which has raised the likelihood
of a link between these two phenomena. In this scenario, maternal microbiota is a possible linking
mechanistic pathway. According to the “Developmental Origins of Health and Disease” paradigm,
environmental exposures (in utero and early life) can permanently alter the body’s structure, physiology,
and metabolism, increasing illness risk and/or speeding up disease progression in offspring,
adults, and even generations. Nutritional exposure during early developmental stages may induce
susceptibility to the later development of human diseases via interactions in the microbiome, including
alterations in brain function and behavior of offspring, as explained by the gut–brain axis theory.
This review provides an overview of the implications of maternal nutrition on neurodevelopmental
disorders and the establishment and maturation of gut microbiota in the offspring. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Gut microbiota | pt_BR |
| Subject | Neurodevelopmental disorders | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Gut–brain axis | pt_BR |
| Subject | Maternal diet | pt_BR |
