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ROLE OF MATERNAL MICROBIOTA AND NUTRITION IN EARLY-LIFE NEURODEVELOPMENTAL DISORDERS
Distúrbios do neurodesenvolvimento
Obesidade
Eixo intestino-cérebro
Dieta materna
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Abstract
The rise in the prevalence of obesity and other related metabolic diseases has been paralleled
by an increase in the frequency of neurodevelopmental problems, which has raised the likelihood
of a link between these two phenomena. In this scenario, maternal microbiota is a possible linking
mechanistic pathway. According to the “Developmental Origins of Health and Disease” paradigm,
environmental exposures (in utero and early life) can permanently alter the body’s structure, physiology,
and metabolism, increasing illness risk and/or speeding up disease progression in offspring,
adults, and even generations. Nutritional exposure during early developmental stages may induce
susceptibility to the later development of human diseases via interactions in the microbiome, including
alterations in brain function and behavior of offspring, as explained by the gut–brain axis theory.
This review provides an overview of the implications of maternal nutrition on neurodevelopmental
disorders and the establishment and maturation of gut microbiota in the offspring.
Keywords in Portuguese
Microbiota intestinalDistúrbios do neurodesenvolvimento
Obesidade
Eixo intestino-cérebro
Dieta materna
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