Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice

Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil/Centro de Pesquisas Rene Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Department of General Pathology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil
Department of Parasitology. Federal University of Minas Gerais., Belo Horizonte, MG, Brazil
Department of Parasitology. Federal University of Minas Gerais., Belo Horizonte, MG, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil/Department of Parasitology, Microbiology and Immunology.Federal University of Juiz de For a. Juiz de Fora, MG, Brazil
Division of Clinical Immunology and Allergy and Heart Institute. University of São Paulo Medical School. São Paulo, SP, Brazil
Department of Biochemistry and Immunology and Institute for Investigation in Immunology. Millenium Institute. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Abstract

Sm14 and paramyosin are two major Schistosoma mansoni vaccine candidate antigens. Recently, we have identified Sm14 and paramyosin epitopes that are recognized by T cells of resistant individuals living in endemic areas for schistosomiasis. Herein, mice were immunized with these peptides separately or in association in order to evaluate their vaccine potential. Immunization of mice with Sm14 peptides alone or mixed with paramyosin peptides was able to induce 26%-36.7% or 28%-29.2% of worm burden reduction, 67% or 46% of intestinal eggs reduction and also 54%-61% or 43%-52% of liver pathology reduction, respectively. Protection was associated with a Th1 type of immune response induced by Sm14 peptide immunization. In contrast, paramyosin peptide vaccination did not engender protective immunity or liver pathology reduction and immunization was associated with a Th2 type of immune response. (C) 2008 Elsevier B.V. All rights reserved

Keywords

peptide
vaccine
Schistosoma mansoni

Publisher

Elsevier

Citation

GARCIA, Teresa Cristina Melo et al. Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice. Acta Tropica, v. 106, n.3, p. 162-167, 2008. DOI: 10.1016/j.actatropica.2008.03.003

DOI

10.1016/j.actatropica.2008.03.003

ISSN

0001-706X

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/50913

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