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FLAVONOIDS FROM SIPARUNA CRISTATA AS POTENTIAL INHIBITORS OF SARS‑COV‑2 REPLICATION
Siparunaceae
Espectrometria de massa
Flavonóides O-metil
Coronavírus
Siparunaceae
Mass spectrometry
O-Methyl flavonoids
Coronavirus
Author
Affilliation
Abstract
The novel coronavirus SARS-CoV-2 has been affecting the world, causing severe pneumonia and acute respiratory syndrome,
leading people to death. Therefore, the search for anti-SARS-CoV-2 compounds is pivotal for public health. Natural products
may present sources of bioactive compounds; among them, flavonoids are known in literature for their antiviral activity.
Siparuna species are used in Brazilian folk medicine for the treatment of colds and flu. This work describes the isolation of
3,3′,4′-tri-O-methyl-quercetin, 3,7,3′,4′-tetra-O-methyl-quercetin (retusin), and 3,7-di-O-methyl-kaempferol (kumatakenin)
from the dichloromethane extract of leaves of Siparuna cristata (Poepp. & Endl.) A.DC., Siparunaceae, using high-speed
countercurrent chromatography in addition to the investigation of their inhibitory effect against SARS-CoV-2 viral replication.
Retusin and kumatakenin inhibited SARS-CoV-2 replication in Vero E6 and Calu-3 cells, with a selective index greater
than lopinavir/ritonavir and chloroquine, used as control. Flavonoids and their derivatives may stand for target compounds
to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
Keywords in Portuguese
Cromatografia de contracorrenteSiparunaceae
Espectrometria de massa
Flavonóides O-metil
Coronavírus
Keywords
Countercurrent chromatographySiparunaceae
Mass spectrometry
O-Methyl flavonoids
Coronavirus
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