| Author | Martins, Marina Angela | |
| Author | Silva, Maria Luiza | |
| Author | Santos, Silvana Maria Elói | |
| Author | Ribeiro, Jose Geraldo Leite | |
| Author | Pascoal, Vanessa Peruhype Magalhães | |
| Author | Marciano, Ana Paula Vieira | |
| Author | Homma, Akira | |
| Author | Kroon, Erna Geessien | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2022-02-02T14:14:44Z | |
| Available date | 2022-02-02T14:14:44Z | |
| Document date | 2008 | |
| Citation | MARTINS, Marina Angela et al. Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination. Vaccine, v. 26, p. 1173—1118, 2008. doi:10.1016/j.vaccine.2007.12.035 | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/50985 | |
| Sponsorship | INSTITUTO RENé RACHOU | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.vaccine.2007.12.035 | |
| Abstract | Detailed multiparametric phenotypic investigation aiming to characterize the kinetics of the innate immune response in the peripheral blood following 17DD yellow fever (17DD-YF) first-time vaccination was performed. Results showed increased frequency of monocytes and NK cell subpopulations besides unexpected up-regulation of granulocytes activation status (CD28(+)/CD23(+) and CD28(+)/HLA-DR(+), respectively). Up-regulation of Fc gamma-R and IL-10-R expression emerge as putative events underlying the mixed pattern of phenotypic features triggered by the 17DD yellow fever (17DD-YF) vaccination. Mixed pattern of chemokine receptors expression further support our hypothesis that a parallel establishment of activation/ modulation microenvironment plays a pivotal role in the protective immunity triggered by the 17DD-YF vaccine. (C) 2008 Elsevier Ltd. All rights reserved | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pos-graduacao em Patologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedeutica Complementar. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Minas Gerais. Secretaria Estadual de Saude de Minas Gerais. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Biomanguinhos. Rio de Janeiro, RJ, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Strain 17D vaccine | pt_BR |
| Subject | yellow fever | pt_BR |
| Subject | innate immunity | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
