Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination

Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pos-graduacao em Patologia. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedeutica Complementar. Belo Horizonte, MG, Brazil
Minas Gerais. Secretaria Estadual de Saude de Minas Gerais. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Biomanguinhos. Rio de Janeiro, RJ, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, Brazil

Abstract

Detailed multiparametric phenotypic investigation aiming to characterize the kinetics of the innate immune response in the peripheral blood following 17DD yellow fever (17DD-YF) first-time vaccination was performed. Results showed increased frequency of monocytes and NK cell subpopulations besides unexpected up-regulation of granulocytes activation status (CD28(+)/CD23(+) and CD28(+)/HLA-DR(+), respectively). Up-regulation of Fc gamma-R and IL-10-R expression emerge as putative events underlying the mixed pattern of phenotypic features triggered by the 17DD yellow fever (17DD-YF) vaccination. Mixed pattern of chemokine receptors expression further support our hypothesis that a parallel establishment of activation/ modulation microenvironment plays a pivotal role in the protective immunity triggered by the 17DD-YF vaccine. (C) 2008 Elsevier Ltd. All rights reserved

Keywords

Strain 17D vaccine
yellow fever
innate immunity

Publisher

Elsevier

Citation

MARTINS, Marina Angela et al. Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination. Vaccine, v. 26, p. 1173—1118, 2008. doi:10.1016/j.vaccine.2007.12.035

DOI

10.1016/j.vaccine.2007.12.035

ISSN

0264-410X

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/50985

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