Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/51104
Title: Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
Authors: Castro, Caroline T.
Gama, Romana S.
Pereira, Marcos
Oliveira, Marcio G.
Pizzol, Tatiane S. Dal
Barreto, Mauricio L.
Santos, Djanilson B.
Affilliation: Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória da Conquista, BA, Brasil.
Universidade Federal da Bahia. Programa de Pós-Graduação em Medicina e Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Saúde Coletiva. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória da Conquista, BA, Brasil.
Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Saúde Coletiva. Salvador, BA, Brasil. / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória da Conquista, BA, Brasil / Universidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Santo Antônio de Jesus, BA, Brasil.
Abstract: Introduction: A high number of women are exposed to acetaminophen during pregnancy worldwide. This drug safety during pregnancy regarding preterm birth, birth weight, and fetal development has not been well escribed. This study investigated the effect of acetaminophen use during pregnancy on selected adverse pregnancy outcomes. Areas covered: Databases were searched to identify studies reporting the effects of acetaminophen use during pregnancy on preterm birth, low birth weight, and small for gestational age. The studies’ quality was assessed by the Newcastle-Ottawa Scale and the Methodological Index for Non- Randomized Studies. Risk ratios with 95% confidence intervals were estimated using a fixed or random-effects model. Six studies were included for final review, four cohort and two case-control studies. We found no increased risk of preterm birth (RR 0.97; 95% CI 0.59–1.58), and decreased risks of low birth weight (RR 0.65; 95% CI 0.59–0.72) and small for gestational age (RR 0.69; 95% CI 0.50–0.97). Acetaminophen exposure during the third trimester revealed non-significantly in the outcomes. Expert opinion: Exposure to cetaminophen during pregnancy appears to not increase the risk of the outcomes analyzed. However, there is a lack of information regarding the exposure dose and frequency of acetaminophen use.
Keywords: Acetaminophen
Premature Birth
Meta-analysis
Systematic review
keywords: Acetaminofen
Nascimento prematuro
Metanálise
Revisão sistemática
Issue Date: 2022
Publisher: Taylor and Francis
Citation: Castro, Caroline T. et al. Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. Expert Opinion on Drug Safety. v. 21, n. 2, p. 241–251, 2022.
DOI: doi.org/10.1080/14740338.2022.2020246
ISSN: 1474-0338
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos
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