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DECREASED CYTOKINE PLASMA LEVELS AND CHANGES IN T-CELL ACTIVATION ARE ASSOCIATED WITH HEMODYNAMIC IMPROVEMENT AND CLINICAL OUTCOMES AFTER PERCUTANEOUS MITRAL COMMISSUROTOMY IN PATIENTS WITH RHEUMATIC MITRAL STENOSIS
Silva, Vicente Rezende et al. | Date Issued: 2021
Author
Silva, Vicente Rezende
Neves, Eula Graciele Amorin
Passos, Lívia Silva Araújo
Melo, Flávia Cristina de
Carvalho, Andrea Teixeira de
Nassif, Maria Cecília Landim
Junqueira, Lucas Lodi
Aikawa, Elena
Dutra, Walderez Ornelas
Nunes, Maria Carmo Pereira
Affilliation
Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/ Department of Cardiovascular Medicine. The Center for Excellence in Vascular Biology. Brigham and Women's Hospital. Harvard Medical School. Boston, MA, United States.
Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.
Department of Cardiovascular Medicine. The Center for Excellence in Vascular Biology. Brigham and Women's Hospital. Harvard Medical School. Boston, MA, United States.
Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil./Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.
Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.
Abstract
Mitral stenosis (MS) is a consequence of rheumatic heart disease that leads to heart failure requiring mechanical intervention. Percutaneous mitral commissurotomy (PMC) is the treatment of choice for the intervention, and currently there are no soluble markers associated with hemodynamic improvement after PMC. This study aims to determine the changes in cytokine/chemokine plasma levels, as well as T cell activation after PMC, and to investigate their association with immediate hemodynamic improvement and clinical outcomes. Plasma samples from eighteen patients with well-defined MS who underwent PMC and 12 healthy controls were analyzed using BioPlex immunoassay. We observed that 16 out of the 27 (60%) molecules assessed were altered in patients\' plasma pre-PMC as compared to control group. Of those, IL-1 beta, IL-12, IL-6, IL-4, PDGF, and CCL11 showed significant decrease after PMC. Stratifying the patients according to adverse outcome after a 28-month median follow up, we detected a significant reduction of IL-1 beta, IL-12, IL-6, IL-4, IFN-gamma, CXCL-10, VEGF, FGF and PDGF post-PMC in patients without events, but not in those who presented adverse events during the follow-up. Patients with adverse outcomes had lower IL-10 pre-PMC, as compared to the ones without adverse events. In addition, the frequency of CD8+ activated memory cells was increased after PMC, while the frequency of CD4+ activated memory cells did not change. Our results show an association between the decrease of specific cytokines and changes in T cell activation with hemodynamic improvement post-PMC, as well as with long-term outcomes, suggesting their possible use as soluble markers for hemodynamic recovery after MS intervention.
Keywords
T cells
cytokines
mitral stenosis
percutaneous mitral commissurotomy
rheumatic heart disease
 
Publisher
Frontiers Media S.A
Citation
SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020.
ISSN
2297-055X