Stress is a physiological reaction that results from physical or psychological stimuli on the individual. The objective of this study was to investigate whether there is a connection between the hyperactivity profile before exposure to social stress and the appearance of highly aggressive behavior in the mice submitted at the Model of Spontaneous Aggression (MSA). The MSA used as the analysis of the activity profile of each individual the tail suspension test (TST). During the MSA, we observed different categories of behavior in response to social stress: aggressive (AgR), attacked (AgD), and harmonic. When verifying the influence of the activity profile observed in TST on aggressive behavior, we were seen a prevalence of the median mobility profile among the AgR animals, while the majority of animals with a hypoactive profile were categorized as AgD. Therefore, it was observed that there is no specific initial profile that indicates a tendency to become aggressive.