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https://www.arca.fiocruz.br/handle/icict/51727
CHAGAS DISEASE AND SARS-COV-2 COINFECTION DOES NOT LEAD TO WORSE IN-HOSPITAL OUTCOMES
Author
Molina, Israel
Marcolino, Milena Soriano
Pires, Magda Carvalho
Ramos, Lucas Emanuel Ferreira
Silva, Rafael Tavares
Guimarães Júnior, Milton Henriques
Oliveira, Isaias José Ramos de
Carvalho, Rafael Lima Rodrigues de
Nunes, Aline Gabrielle Sousa
Barros, Ana Lara Rodrigues Monteiro de
Scotton, Ana Luiza Bahia Alves
Madureira, Angélica Aparecida Coelho
Farace, Bárbara Lopes
Carvalho, Cíntia Alcantara de
Rodrigues, Fernanda d’Athayde
Anschau, Fernando
Botoni, Fernando Antonio
Nascimento, Guilherme Fagundes
Duani, Helena
Guimarães, Henrique Cerqueira
Alvarenga, Joice Coutinho de
Moreira, Leila Beltrami
Zandoná, Liege Barella
Almeida, Luana Fonseca de
Kopittke, Luciane
Castro, Luís César de
Santos, Luisa Elem Almeida
Cabral, Máderson Alvares de Souza
Ferreira, Maria Angélica Pires
Sampaio
Oliveira, Neimy Ramos de
Assaf, Pedro Ledic
Lopes, Sofia Jarjour Tavares Starling
Fereguetti, Tatiani Oliveira
Santos, Veridiana Baldon dos
Carvalho, Victor Eliel Bastos de
Ramires, Yuri Carlotto
Ribeiro, Antonio Luiz Pinho
Moscoso, Freddy Antonio Brito
Moura, Rogério
Polanczyk, Carísi Anne
Nunes, Maria do Carmo Pereira
Marcolino, Milena Soriano
Pires, Magda Carvalho
Ramos, Lucas Emanuel Ferreira
Silva, Rafael Tavares
Guimarães Júnior, Milton Henriques
Oliveira, Isaias José Ramos de
Carvalho, Rafael Lima Rodrigues de
Nunes, Aline Gabrielle Sousa
Barros, Ana Lara Rodrigues Monteiro de
Scotton, Ana Luiza Bahia Alves
Madureira, Angélica Aparecida Coelho
Farace, Bárbara Lopes
Carvalho, Cíntia Alcantara de
Rodrigues, Fernanda d’Athayde
Anschau, Fernando
Botoni, Fernando Antonio
Nascimento, Guilherme Fagundes
Duani, Helena
Guimarães, Henrique Cerqueira
Alvarenga, Joice Coutinho de
Moreira, Leila Beltrami
Zandoná, Liege Barella
Almeida, Luana Fonseca de
Kopittke, Luciane
Castro, Luís César de
Santos, Luisa Elem Almeida
Cabral, Máderson Alvares de Souza
Ferreira, Maria Angélica Pires
Sampaio
Oliveira, Neimy Ramos de
Assaf, Pedro Ledic
Lopes, Sofia Jarjour Tavares Starling
Fereguetti, Tatiani Oliveira
Santos, Veridiana Baldon dos
Carvalho, Victor Eliel Bastos de
Ramires, Yuri Carlotto
Ribeiro, Antonio Luiz Pinho
Moscoso, Freddy Antonio Brito
Moura, Rogério
Polanczyk, Carísi Anne
Nunes, Maria do Carmo Pereira
Affilliation
PROSICS Barcelona, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron. Barcelona, Spain / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Department of Internal Medicine. Medical School and Telehealth Center.University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, Brazil / Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.
Department of Statistics. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Statistics. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Statistics. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Marcio Cunha. Ipatinga, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.
Hospital UNIMED BH. Belo Horizonte, MG, Brazil.
Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte, MG, Brazil / Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Regional Antônio Dias. Patos de Minas, MG, Brazil.
Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte, MG, Brazil / Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brazil.
Hospital João XXIII. Belo Horizonte, MG, Brazil.
Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil.
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Porto Alegre, MG, Brazil / Grupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Porto Alegre, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil / Hospital Julia Kubitschek. Belo Horizonte, MG, Brazil.
Hospital UNIMED BH. Belo Horizonte, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil / Internal Medicine Department. University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brazil.
Hospital João XXIII. Belo Horizonte, MG, Brazil.
Institute for Health Technology Assessment. Porto Alegre, RS, Brazil / Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil.
Universidade do Vale do Taquari. Lajeado, RS, Brazil / Hospital Bruno Born. Lajeado, RS, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Porto Alegre, RS, Brazil / Grupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brazil.
Universidade do Vale do Taquari. Lajeado, RS, Brazil/Hospital Bruno Born. Lajeado, RS, Brazil.
Hospital Regional Antônio Dias. Patos de Minas, MG, Brazil / Centro Universitário de Patos de Minas. Patos de Minas, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil / Internal Medicine Department. University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil..
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.
Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte, MG, Brazil.
Hospital Julia Kubitschek. Belo Horizonte, MG, Brazil / Pontífica Universidade Católica de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Porto Alegre, RS, Brazil / Grupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brazil.
Hospital Julia Kubitschek. Belo Horizonte, RS, Brazil / Pontífica Universidade Católica de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Bruno Born. Lajeado, RS, Brazil.
Department of Internal Medicine. Medical School and Telehealth Center. University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, RS, Brazil / Institute for Health Technology Assessment, RS, Porto Alegre, Brazil.
Medical School of Fundação Educacional do Município de Assis. Assis, SP, Brazil.
Hospital Balbino - Rede D`or São Luiz. Rio de Janeiro, RJ, Brazil.
Institute for Health Technology Assessment. Porto Alegre, RS, Brazil/ Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil / Medicine Department. Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, RS, Brazil / Internal Medicine Department. University Hospital. Universidade Federal de Minas. Belo Horizonte, RS, Brazil.
Department of Internal Medicine. Medical School and Telehealth Center.University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, Brazil / Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.
Department of Statistics. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Statistics. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Statistics. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Marcio Cunha. Ipatinga, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.
Hospital UNIMED BH. Belo Horizonte, MG, Brazil.
Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte, MG, Brazil / Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Regional Antônio Dias. Patos de Minas, MG, Brazil.
Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte, MG, Brazil / Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brazil.
Hospital João XXIII. Belo Horizonte, MG, Brazil.
Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil.
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Porto Alegre, MG, Brazil / Grupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Porto Alegre, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil / Hospital Julia Kubitschek. Belo Horizonte, MG, Brazil.
Hospital UNIMED BH. Belo Horizonte, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil / Internal Medicine Department. University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Risoleta Tolentino Neves. Belo Horizonte, MG, Brazil.
Hospital João XXIII. Belo Horizonte, MG, Brazil.
Institute for Health Technology Assessment. Porto Alegre, RS, Brazil / Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil.
Universidade do Vale do Taquari. Lajeado, RS, Brazil / Hospital Bruno Born. Lajeado, RS, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Porto Alegre, RS, Brazil / Grupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brazil.
Universidade do Vale do Taquari. Lajeado, RS, Brazil/Hospital Bruno Born. Lajeado, RS, Brazil.
Hospital Regional Antônio Dias. Patos de Minas, MG, Brazil / Centro Universitário de Patos de Minas. Patos de Minas, MG, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil / Internal Medicine Department. University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil..
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.
Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte, MG, Brazil.
Hospital Julia Kubitschek. Belo Horizonte, MG, Brazil / Pontífica Universidade Católica de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Porto Alegre, RS, Brazil / Grupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brazil.
Hospital Julia Kubitschek. Belo Horizonte, RS, Brazil / Pontífica Universidade Católica de Minas Gerais. Belo Horizonte, MG, Brazil.
Hospital Bruno Born. Lajeado, RS, Brazil.
Department of Internal Medicine. Medical School and Telehealth Center. University Hospital. Universidade Federal de Minas Gerais. Belo Horizonte, RS, Brazil / Institute for Health Technology Assessment, RS, Porto Alegre, Brazil.
Medical School of Fundação Educacional do Município de Assis. Assis, SP, Brazil.
Hospital Balbino - Rede D`or São Luiz. Rio de Janeiro, RJ, Brazil.
Institute for Health Technology Assessment. Porto Alegre, RS, Brazil/ Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil / Medicine Department. Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil.
Medical School. Universidade Federal de Minas Gerais. Belo Horizonte, RS, Brazil / Internal Medicine Department. University Hospital. Universidade Federal de Minas. Belo Horizonte, RS, Brazil.
Abstract
Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.
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