| Author | Waghabi, Mariana Caldas | |
| Author | Ferreira, Roberto Rodrigues | |
| Author | Abreu, Rayane da Silva | |
| Author | Degrave, Wim | |
| Author | Souza, Elen Mello de | |
| Author | Bailly, Sabine | |
| Author | Feige, Jean-Jacques | |
| Author | Araújo-Jorge, Tania C. de | |
| Access date | 2022-03-21T18:21:25Z | |
| Available date | 2022-03-21T18:21:25Z | |
| Document date | 2022 | |
| Citation | WAGHABI, Mariana Caldas et al. Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 117, e210395, p. 1 - 2, 2022. | pt_BR |
| ISSN | 0074-0206 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51785 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Fator de crescimento transformador beta | pt_BR |
| Subject in Portuguese | Terapêutica | pt_BR |
| Subject in Portuguese | Target | pt_BR |
| Subject in Portuguese | Cardíaco | pt_BR |
| Subject in Portuguese | Dano | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Title | Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760210395 | |
| Abstract | Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been
investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Important
observations have been made, such as: (i) the ability of Trypanosoma cruzi in activating latent TGF-β; (ii) the potential involvement
of TGF-β pathway on T. cruzi invasion of host cells; (iii) association of TGF-β with parasite intracellular replication; (iv) cardiac
fibrosis development and maintenance; (v) disruption of Connexin-43 plaque structures and (vi) inflammation and immune
response. In this perspective article we intend to discuss the advances of the potential use of new therapies targeting TGF-β to
treat the cardiac alterations of Chagas disease-affected patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJJ, Brasil. | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Biology of Cancer and Infection Laboratory. Grenoble, France. | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Biology of Cancer and Infection Laboratory. Grenoble, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Transforming growth factor beta | pt_BR |
| Subject | Therapeutic | pt_BR |
| Subject | Target | pt_BR |
| Subject | Cardiac | pt_BR |
| Subject | Damage | pt_BR |
| Subject | Chagas disease | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
