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Sustainable Development Goals
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- IOC - Artigos de Periódicos [12978]
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TRANSFORMING GROWTH FACTOR-ß AS A THERAPEUTIC TARGET FOR THE CARDIAC DAMAGE OF CHAGAS DISEASE
Terapêutica
Target
Cardíaco
Dano
Doença de Chagas
Author
Affilliation
Abstract
Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been
investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Important
observations have been made, such as: (i) the ability of Trypanosoma cruzi in activating latent TGF-β; (ii) the potential involvement
of TGF-β pathway on T. cruzi invasion of host cells; (iii) association of TGF-β with parasite intracellular replication; (iv) cardiac
fibrosis development and maintenance; (v) disruption of Connexin-43 plaque structures and (vi) inflammation and immune
response. In this perspective article we intend to discuss the advances of the potential use of new therapies targeting TGF-β to
treat the cardiac alterations of Chagas disease-affected patients.
Keywords in Portuguese
Fator de crescimento transformador betaTerapêutica
Target
Cardíaco
Dano
Doença de Chagas
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