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THE ROLE OF HIGH-RISK GEOGRAPHIES IN THE PERPETUATION OF THE HIV EPIDEMIC IN RURAL SOUTH AFRICA: A SPATIAL MOLECULAR EPIDEMIOLOGY STUDY
Cuadros, Diego F. et al. | Date Issued: 2022
Author
Cuadros, Diego F.
Oliveira, Tulio de
Gräf, Tiago
Junqueira, Dennis M.
Wilkinson, Eduan
Lemey, Philippe
Bärnighausen, Till
Kim, Hae-Young
Tanser, Frank
Affilliation
Department of Geography and Geographic Information Science. University of Cincinnati. Cincinnati, OH, United States of America / Health Geography and Disease Modeling Laboratory. University of Cincinnati. Cincinnati, OH, United States of America.
KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa / School of Laboratory Medicine and Medical Science. Department of Health Sciences
KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa / School of Laboratory Medicine and Medical Science. Department of Health Sciences. University of KwaZulu-Natal. Durban, South Africa.
KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa / School of Laboratory Medicine and Medical Science. Department of Health Sciences. University of KwaZulu-Natal. Durban, South Africa.
Department of Microbiology and Immunology. Rega Institute for Medical Research. University of Leuven, Leuven, Belgium.
Africa Health Research Institute. University of KwaZulu-Natal. Durban, South Africa / Heidelberg Institute for Public Health. University of Heidelberg. Heidelberg, Germany / Department of Global Health and Population. Harvard T.H. Chan School of Public Health. Boston, MA, United States of America.
Africa Health Research Institute. University of KwaZulu-Natal. Durban, South Africa / Department of Population Health. New York University Grossman School of Medicine. New York, NY, United States of America.
Africa Health Research Institute. University of KwaZulu-Natal. Durban, South Africa / School of Nursing and Public Health. University of KwaZulu-Natal. Durban, South Africa / Lincoln International Institute for Rural Health. University of Lincoln, Lincoln, United Kingdom / Centre for the AIDS Programme of Research in South Africa. University of KwaZulu-Natal. Durban, South Africa.
Abstract
In this study, we hypothesize that HIV geographical clusters (geospatial areas with significantly higher numbers of HIV positive individuals) can behave as the highly connected nodes in the transmission network. Using data come from one of the most comprehensive demographic surveillance systems in Africa, we found that more than 70% of the HIV transmission links identified were directly connected to an HIV geographical cluster located in a peri-urban area. Moreover, we identified a single central large community of highly connected nodes located within the HIV cluster. This module was composed by nodes highly connected among them, forming a central structure of the network that was also connected with the small sparser modules located outside of the HIV geographical cluster. Our study supports the evidence of the high level of connectivity between HIV geographical high-risk populations and the entire community.
Keywords in Portuguese
HIV
Transmissão de Doença Infecciosa
África
 
Keywords
HIV
Disease Transmission, Infectious
Africa
 
Keywords in Spanish
VIH
Transmisión de Enfermedad Infecciosa
África
 
Publisher
Public Library of Science
Citation
CUADROS, Diego F. et al. The role of high-risk geographies in the perpetuation of the HIV epidemic in rural South Africa: a spatial molecular epidemiology study. PLOS Global Public Health, v. 2, n. 2, 2022.
DOI
10.1371/journal.pgph.0000105
ISSN
2767-3375