Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/52664
Title: Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
Authors: Ferreira, Marcela de Faria
Brito-Santos, Fabio
Theodoro, Pedro Henrique Nascimento
Almeida, Marcos de Abreu
Lazera, Marcia dos Santos
Trilles, Luciana
Affilliation: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Abstract: We present a rare condition of mixed C. neoformans and C. gattii infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis. Signs and symptoms are relative to respiratory tract and skin, confounding with other opportunistic disease. After negatives CrAg LFA and Indian ink staining in CSF, there was isolation of C. gattii in sputum and C. neoformans in CSF, in addition to reagent serology (double immunodiffusion) for PCM with 1/16 titer. The patient was treated with amphotericin B and TMP-SMX with good clinical response and recovery of cellular immunity after initiation of antiretroviral therapy.
Keywords: Cryptococcal antigen (CrAg)
Cryptococcosis
HIV
Lateral Flow Assay (LFA)
Paracoccidioidomycosis
Issue Date: 2022
Publisher: Elsevier
Citation: FERREIRA, Marcela de Faria et al. Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV. Medical mycology case reports, v. 35, p. 48-50, 2022
DOI: 10.1016/j.mmcr.2022.01.006
ISSN: 2211-7539
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos
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