Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/52665
Title: Implantação do mixoma infeccioso do coelho na câmara anterior do ôlho da cobaia
Authors: Torres, C. Magarinos
Cardoso, Rita A. de Almeida
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Divisão de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Divisão de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: Mammalian cancer as well as the Rous chicken sarcoma has been successfully transplanted into the anterior chamber of the eyes of guinea pigs. It was of interest, therefore, to see if the infectious myxomatosis of rabbits, another representative of the infectious tumors, could be grown in the anterior chamber of the guinea pig eye, and, if growth occurred, to compare the tumor's behaviour with that of growths of the above mentioned etiology. Forty-three full-grown guinea pigs from mixed stocks were used throughout, and seventy-eight heterologous transplantation experiments were performed. The grafts measuring less than 2 mm. in diameter were cut from the subcutaneous tissue in skin lesions of rabbits with infectious myxomatosis recently killed. The transfer to the anterior chamber was performed after the usual technique. Some degree of partial survival was found in 23,8% of the grafts, in which typical myxoma cells could be demonstrated fifteen days after the transplantation. The transplant apparently does not increase in size, differing in that respect from that of the Rous chicken sarcoma, which increases in size by 2 or 3 diameters in 2 weeks (Shrigley, Greene & Duran-Reynals, 1945). The virus was still alive in 26% of the grafts 21 days after transplantation, and was able to induce a typical disease when injected to normal rabbits. No alteration in the properties of the virus after growth in the guinea pig was noticed, and this also is different from what happens with the Rous chicken sarcoma.
Issue Date: 1948
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
Citation: TORRES, C. Magarinos; CARDOSO, Rita A. de Almeida. Implantação do mixoma infeccioso do coelho na câmara anterior do ôlho da cobaia. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 46, n. 3, p. 1 - 17, 1948.
DOI: 10.1590/S0074-02761948000300004
ISSN: 0074-0206
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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